标题：外周血NLR在无症状卵巢上皮癌早期诊断中的价值

      作者：王芳，张阳，李大兵    (连云港市第一人民医院妇科，江苏 连云港 222002)

      卷次： 2017年28卷8期

      【摘要】 目的 探讨外周血中性粒细胞/淋巴细胞比值(NLR)在卵巢上皮癌筛查和早期诊断中的价值。方法 选取 2013年 6月至 2016年 8月我院收治的卵巢上皮性癌患者 71例(病例组)和健康对照组 65例，比较两组间NLR水平，并通过ROC曲线及最佳诊断界值点(DCP)评估外周血NRL预测卵巢上皮癌的价值。结果 病例组患者的NLR水平(3.00±2.63)高于健康对照组(1.64±0.64)，差异有显著统计学意义(P<0.01)；NLR的ROC曲线下面积为0.727，最佳DCP为 2.00，灵敏度、特异度、准确度、阳性预测值、阴性预测值分别为 61.97%(44/71)、81.54%(53/65)、71.32%(97/136)、78.57%(44/56)、66.25%(53/80)。结论 NLR对卵巢上皮癌的诊断具有一定价值，可用于卵巢上皮性肿瘤的初步筛查和早期诊断。
      【关键词】 卵巢癌；中性粒细胞/淋巴细胞比值；ROC曲线；诊断
      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2017）08—1283—02

Value of peripheral blood NLR in early diagnosis of asymptomatic epithelial ovarian cancer.
WANG Fang, ZHANGYang, LI Da-bing. Department of Gynecology, the First People's Hospital of Lianyungang, Lianyungang 222002, Jiangsu, CHINA
【Abstract】 Objective To investigate the value of peripheral neutrophil-to-lymphocyte ratio (NLR) in screen-ing and early diagnosis of epithelial ovarian cancer. Methods A total of 71 patients of epithelial ovarian cancer and 65cases of healthy controls were selected from June 2013 and August 2016. The level of NLR was compared among thetwo groups. The ROC curve and diagnostic critical point (DCP) were analyzed to evaluate the predictive value of NLR.Results The NLR in epithelial ovarian cancer group were significantly higher than that in healthy controls group,(3.00±2.63) vs (1.64±0.64), P<0.01. Area under the ROC curve for NLR levels was 0.727, and the cut-off value of DCPof NLR was 2.00, with the sensitivity of 61.97% (44/71), specificity of 81.54% (53/65), accuracy of 71.32% (97/136),positive predictive value of 78.57% (44/56), and negative predictive value of 66.25% (53/80). Conclusion The NLR isvaluable for the diagnosis of ovarian epithelial carcinoma, which can be used for screening and early diagnosis of epithe-lial ovarian cancer.
      【Key words】 Ovarian cancer; Neutrophil-to-lymphocyte ratio; ROC Curve; Diagnosis·论 著·doi:10.3969/j.issn.1003-6350.2017.08.027