标题：微创侧脑室引流联合尿激酶灌注治疗自发性脑室出血临床分析

      作者：李汉城，邱平华，谢乐辉    (揭阳市人民医院神经外科，广东 揭阳 522000)

      卷次： 2017年28卷7期

      【摘要】 目的 探讨微创侧脑室引流联合尿激酶灌注治疗自发性脑室出血的临床疗效。方法 回顾性分析我院神经外科于2010年1月至2015年12月期间收治的72例自发性脑室出血患者的临床资料，将其中12例采用内科保守治疗的患者纳入对照组，60例采用微创侧脑室引流联合尿激酶灌注治疗的患者纳入观察组，对患者进行6个月的随访，比较两组患者的脑积水发生率及临床疗效。结果 两组患者随访6个月时，观察组患者的治疗良好率为66.67%，明显高于对照组的33.33%，差异有统计学意义(P<0.05)；观察组患者的脑积水发生率为16.67%，明显低于对照组的41.67%，差异有统计学意义(P<0.05)。结论 微创侧脑室穿刺引流联合尿激酶灌注治疗自发性脑室出血临床疗效确切，且可以降低脑积水并发症的发生率，进而改善患者的预后。
      【关键词】 自发性脑室出血；侧脑室引流；尿激酶；日常生活能力
      【中图分类号】 R743.34 【文献标识码】 A 【文章编号】 1003—6350（2017）07—1150—03

Clinical analysis of minimally invasive lateral external drainage combined with urokinase infusion in thetreatment of spontaneous ventricular hemorrhage.
LI Han-cheng, QIU Ping-hua, XIE Le-hui. Department ofNeurosurgery, the People's Hospital of Jieyang City, Jieyang 522000, Guangdong, CHINA
【Abstract】 Objective To investigate the clinical effect of minimally invasive lateral external drainage com-bined with urokinase infusion in the treatment of spontaneous ventricular hemorrhage. Methods The clinical data of 72cases of spontaneous intraventricular hemorrhage patients treated in Department of Neurosurgery of our hospital fromJanuary 2010 to December 2015 was retrospectively analyzed. Twelve cases with conservative medical treatment wereincluded into the control group, and sixty cases with lateral external drainage combined with urokinase infusion treat-ment were included into the observation group, which were followed up for 6 months. The incidence of hydrocephalusand clinical curative effect were compared between the two groups. Results After 6 months of follow-up, the good rateof treatment in the observation group was 66.67%, which was significantly higher than 33.33% in the control group (P<0.05). The incidence of hydrocephalus in the observation group was 16.67%, which was significantly lower than 41.67%in the control group (P<0.05). Conclusion Minimally invasive lateral external drainage combined with urokinase infu-sion in the treatment of spontaneous ventricular hemorrhage has a definite curative effect, which can reduce the inci-dence of hydrocephalus complications, thereby improving the prognosis of patients .
      【Key words】 Spontaneous ventricular hemorrhage; Lateral ventricle drainage; Urokinase; Daily living ability·临床经验·doi:10.3969/j.issn.1003-6350.2017.07.041