标题：葡萄胎中E-cadherin和Laminin的表达及临床意义

      作者：张力鹏，丁岩    (新疆医科大学第一附属医院，新疆 乌鲁木齐 830054)

      卷次： 2017年28卷6期

      【摘要】 目的 探讨 E-cadherin和 Laminin对部分性葡萄胎、完全性葡萄胎和侵蚀性葡萄胎的诊断价值。方法 收集 2005年 1月至 2016年 3月新疆医科大学第一附属医院妇科 75例患者的葡萄胎组织，石蜡包埋组织，采用免疫组化 SP法检测包埋组织中E-cadherin和Laminin的表达水平，其中部分性葡萄胎 25例，完全性葡萄胎36例，侵蚀性葡萄胎14例。结果 按部分性葡萄胎、完全性葡萄胎和侵蚀性葡萄胎顺序，E-cadherin阳性检出率分别为 88.0% (22/25)、69.4% (25/36)和 35.7% (5/14)，表达依次降低，差异有统计学意义(χ2=11.539，P=0.003)；Laminin阳性检出率分别为 84.0% (21/25)、72.2% (26/36)和 28.6% (4/14)，表达依次降低，差异有统计学意义(χ2=12.648，P=0.002）。结论 免疫组化法分析E-cadherin和Laminin可以作为不同类型葡萄胎传统诊断方法的辅助手段。
      【关键词】 葡萄胎；E-cadherin；Laminin；免疫组织化学；SP法
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2017）06—0875—03

Immunohistochemical analysis of E-cadherin and Laminin in hydatidiform mole.
ZHANG Li-peng, DING Yan. TheFirst Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, CHINA
【Abstract】 Objective To investigate the role of E-cadherin and Laminin in the differential diagnosis of partialhydatidiform mole (PHM), complete hydatidiform mole (CHM) and invasive hydatidiform mole (IHM). Methods FromJanuary 2005 to March 2016, 75 cases of hydatidiform mole tissues were collected in Department of Gynaecology, theFirst Affiliated Hospital of Xinjiang Medical University. Hydatidiform mole tissues were paraffin embedded. E-cadherinand Laminin expression were investigated by immunohistochemically SP methods in paraffin-embedded tissue sections,including diagnosed cases of PHM (n=25), CHM (n=36) and HA (n=14). Results From PHMs to CHMs to IHMs, posi-tive detection rate of E-cadherin were 88.0% (22/25), 69.4% (25/36) and 35.7% (5/14) respectively, with statistically sig-nificant differences (χ2=11.539, P=0.003). Positive detection rate of E-cadherin were 84.0% (21/25), 72.2% (26/36) and28.6% (4/14) respectively, and there were statistically significant differences (χ2=12.648, P=0.002). Conclusion Immu-nohistochemical analysis of E-cadherin and Laminin expression could serve as a useful adjunct to conventional methodsin the differential diagnosis of PHM, CHM and IHM.
      【Key words】 Hydatidiform mole; E-cadherin; Laminin; Immunohistochemistry; SP method·论 著·doi:10.3969/j.issn.1003-6350.2017.06.004基金项目：国家自然科学基金（编号：81660249）