标题：Wnt信号通路在神经发生中的作用

      作者：张彬渝，余永莉    (遵义医学院珠海校区人体解剖与组织胚胎教研室，广东 珠海 519041)

      卷次： 2017年28卷5期

      【摘要】 Wnt信号通路在哺乳动物的生长发育过程中调节细胞的增殖、分化、迁移和极化等过程。Wnt信号通路与神经发生关系密切，大量的研究显示，该通路突变或异常可产生诸多神经系统疾病。Wnt信号通路的失调还与癌症、神经退行性疾病的发生密切相关。研究发现，成年哺乳动物脑细胞受损后Wnt信号通路会被启动，从而促进神经干细胞的再生。本文从Wnt信号通路出发，通过分析Wnt信号通路在神经发生中的作用，有助于深入理解神经发育过程中Wnt信号通路的作用机制。
      【关键词】 Wnt信号通路；神经发生；癌症；神经系统疾病
      【中图分类号】 R741.04 【文献标识码】 A 【文章编号】 1003—6350（2017）05—0791—04

Function of WNT signaling pathways in neurogenesis.
ZHANG Bin-yu, YU Yong-li. Department of Human Anatomyand Histoembryology, Zhuhai Campus, Zunyi Medical College, Zhuhai 519041, Guangdong, CHINA【Abstract】 WNT (Wingless-type MMTV integration site family member) signaling pathways regulate cellularproliferation, differentiation, migration, and polarization during mammalian growth and development. WNT signalingpathways are closely related to neural genesis and many researches have shown that mutation and anomaly in WNT sig-naling pathways may lead to many neural-related diseases. Disorders in WNT Signaling Pathways are also closely con-nected to the genesis of cancer, diabetes, and neuro-degenerative diseases. Researchers have found that WNT signalingpathways will be activated after adult mammalian brain cells are damaged, which will stimulate the regeneration of neu-ral stem cells. In this paper, we analyze the role of WNT signaling pathways in neurogenesis, which contribute to the un-derstanding of the role of WNT signaling pathways in neural development process.
      【Key words】 Wnt signaling; Neurogenesis; Cancer; Nervous system disease·综 述·doi:10.3969/j.issn.1003-6350.2017.05.035