标题：宫颈癌子宫切除术对患者机体免疫功能的影响

      作者：欧武英 1，陈芳 2，王永卿 1，蔡丽云 1    (海口市人民医院检验科 1、妇产科 2，海南 海口 570208)

      卷次： 2017年28卷5期

      【摘要】 目的 探讨宫颈癌子宫切除术对患者免疫球蛋白G (IgG)与C反应蛋白(CRP)的影响。方法 选择海口市人民医院妇产科2012年5月至2015年11月收治的80例宫颈癌患者，参照抽签法分为对照组和观察组，每组40例，对照组患者行开腹子宫切除术，观察组患者行腹腔镜子宫切除术，比较两组患者的手术情况、术后 IgG、CRP、补体C3及C4水平变化，以及并发症情况。结果 观察组患者的手术出血量、手术时间、排气时间均优于对照组，差异均有统计学意义(P<0.05)；术后，观察组患者的 IgG为(8.34±1.12) ng/L，高于对照组的(6.30±0.83) ng/L，CRP(22.15±4.21) mg/L，低于对照组的(35.28±5.37) mg/L，差异均有统计学意义(P<0.05)；治疗后，观察组患者补体C3和C4水平分别为(0.87±0.04) g/L、(0.21±0.01) g/L，明显高于对照组的(0.75±0.02) g/L和(0.17±0.02) g/L，差异均有统计学意义(P<0.05)；术后观察组总并发症为 10.0%，明显低于对照组的 30.0%，差异有统计学意义(P<0.05)。结论 宫颈癌子宫切除术能够产生应激反应，使血清 IgG水平降低、CRP水平上升，但腹腔镜下手术的应激反应相对较轻，值得推广。
      【关键词】 宫颈癌；子宫切除术；免疫球蛋白 IgG；C反应蛋白；腹腔镜；应激反应
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2017）05—0766—03

Effect of laparoscopic hysterectomy on immunological function in patients with cervical cancer.
OU Wu-ying 1,CHEN Fang 2, WANG Yong-qing 1, CAI Li-yun 1. Department of Clinical Laboratory 1, Department of Obstetrics andGynecology 2, Haikou People's Hospital, Haikou 570208, Hainan, CHINA
【Abstract】 Objective To investigate the effect of hysterectomy on immunoglobulin G (IgG) and C-reactiveprotein (CRP) in patients with cervical cancer. Methods Eighty patients with cervical cancer admitted to Haikou Peo-ple's Hospital from May 2012 to November 2015 were divided into the control group and the observation group accord-ing to the method of lottery, with 40 patients in each group. The patients in the control group were treated by open hys-terectomy, and the patients in the observation group underwent laparoscopic hysterectomy. The changes of IgG, CRP,complement C3 and C4 levels and the complications were compared between the two groups. Results The surgicalblood loss, operating time and exhaust time of the observation group were significantly better than those of the controlgroup (P<0.05). After treatment, IgG in the observation group was (8.34±1.12) ng/L, which was significantly higherthan (6.30±0.83) ng/L of the control group; CRP in the observation group was (22.15±4.21) mg/L, which was significant-ly lower than (35.28±5.37) mg/L of the control group (P<0.05). After treatment, the levels of complement C3 and C4 inthe observation group were respectively (0.87±0.04) and (0.21±0.01), which were significantly higher than (0.75±0.02)and (0.17±0.02) in the control group (P<0.05). The total complication rate in the observation group was 10.0%, whichwas significantly lower than 30.0% in the control group (P<0.05). Conclusion Hysterectomy of cervical cancer canproduce stress response, decrease the level of serum IgG and raise the level of CRP. However, the stress reaction of lapa-roscopic surgery is relatively light, which is worth popularizing.
      【Key words】 Cervical carcinoma; Hysterectomy; Immunoglobulin G (IgG); C-reactive protein (CRP); Laparosco-py; Stress response·论 著·doi:10.3969/j.issn.1003-6350.2017.05.027