标题：深圳某社区非户籍女性HPV感染与宫颈鳞状上皮内病变的相关性研究

      作者：陈秋梅 1，3，汪皓 2，郭恒 1，魏晟 1    (1.华中科技大学同济医学院公共卫生学院流行病与卫生统计学，湖北 武汉 430030；2.南方医科大学附属深圳市妇幼保健院保健部，广东 深圳 518028；3.深圳市宝安区妇幼保健院妇产科，广东 深圳 518133)

      卷次： 2017年28卷5期

      【摘要】 目的 了解深圳市宝安区非户籍妇女人类乳头状瘤病毒(HPV)感染与宫颈鳞状上皮内病变(SIL)之间的相关性。方法 多阶段分层抽样对2015年6月至2016年6月深圳市宝安区12个社区5 391名妇女进行宫颈HPV基因型检测，初筛阳性1 445例再进行液基细胞学技术(TCT)检测。运用单因素Logistic回归分析宫颈病变与HPV亚型的相关性。结果 HPV阳性中最常见的5种基因型为HPV16 (9.56%)、HPV58 (8.52%)、HPV52 (6.92%)、HPV18 (6.31%)、HPV6 (5.65%)。未见上皮内病变/恶性细胞(NILM)组和高度鳞状上皮内病变(HSIL)组中高危型HPV比例分别为 26.99%、96.88%。单因素Logistic回归分析结果显示，NILM与HPV6、HPV11、HPV43有相关性，LSIL病变与 HPV35、HPV51、HPV56相关，ASC-US病变与 HPV31、HPV39相关。HSIL+组 HPV16、HPV33和HPV58感染的风险较非HSIL+组明显升高。结论 特定高危型 HPV基因型与宫颈高度鳞状上皮内病变有相关性，尤其HPV16、HPV33、HPV58感染，可为宫颈癌防治提供参考依据。
      【关键词】 人类乳头瘤病毒；细胞学；鳞状上皮内病变；感染
      【中图分类号】 R373.9 【文献标识码】 A 【文章编号】 1003—6350（2017）05—0720—04

Correlation between HPV infection and cervical squamous intraepithelial lesions in non-native women incommunities of Shenzhen.
CHEN Qiu-mei 1,3, WANG Hao 2, GUO Heng 1, WEI Sheng 1. 1. Department of Epidemiology andHealth Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430030, Hubei, CHINA; 2. Healthcare Department, Southern Medical University Affiliated Shenzhen Maternity and ChildHealthcare Hospital, Shenzhen 518028, Guangdong, CHINA; 3. Shenzhen Baoan District Maternal and Child HealthcareHospital, Shenzhen 518133, Guangdong, CHINA
【Abstract】 Objective To investigate the association between human papilloma virus (HPV) infection and cer-vical squamous intraepithelial lesions (SILs) for non-native women in Baoan District of Shenzhen. Methods A total of5 391 women were recruited by multi-stage stratified sampling method for cervical cancer screening in 12 communitiesin Baoan District of Shenzhen from June 2015 to June 2016. Exfoliated cervical cells were collected to detect the HPVgenotype. A total of 1 445 HPV-infected samples were tested by liquid thin-layer cytology technology (TCT). Logistic re-gression analysis was used to analyze the correlation between HPV genotypes and cervical squamous intraepithelial le-sions. Results The five most common HPV genotypes were HPV16 (9.56%), followed by HPV58 (8.52%), HPV52(6.92%), HPV18 (6.31%), HPV6 (5.65%). The ratio of high risk (HR)-HPV genotypes in Negative for Intraepithelial Le-sions or Malignancy (NILM) and high-grade SIL (HSIL) or worse (HSIL + ) were 26.99% and 96.88% , respectively.HPV6, HPV11 and HPV43 were related to NILM, while HPV35, HPV51, HPV56 were related to LSIL. HPV31, HPV39were related to atypical squamous cells of undetermined significance (ASC-US). HPV16, HPV33, HPV58 infection maylead to HSIL+. Conclusion There are correlations between high-grade SILs and high risk HPV genotypes, especiallyHPV16, HPV33, HPV58 infection, which provide evidences for prevention and intervention of cervical cancer.
      【Key words】 Human papilloma virus (HPV); Cytology; Cervical squamous intraepithelial lesions; Infection·论 著·doi:10.3969/j.issn.1003-6350.2017.05.011基金项目：广东省深圳市宝安区科技创新局课题(编号：2014069)