标题：健康人群颈动脉斑块形成的检出率及其危险因素

      作者：陆继强 1，沈振海 1，陆昀 1，祁华金 1，王凌 1，范纯 1，金云芳 2    (太湖康复医院超声影像科 1、精神卫生中心 2，江苏 无锡 214000)

      卷次： 2017年28卷5期

      【摘要】 目的 了解健康人群颈动脉斑块形成的情况，并探讨其危险因素，以减少心血管事件的发生。方法 抽取我院 2015年 1~10月期间健康体检人群中行颈动脉检查的 1 014例资料，根据体检结果分为斑块组(98例)和无斑块组(916例)，结合问卷调查以及生化检查中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血尿酸(UA)、空腹血糖(FBG)、糖化血红蛋白（HbA1c）等指标，先进行单因素分析，再将与颈动脉斑块形成的相关变量纳入Logistic回归分析，得出主要独立危险因素。结果 两组人群中年龄、性别、吸烟、饮酒、血压、FBG、HbA1c、LDL-C比较，差异均有统计学意义(P<0.05)；盐摄入、运动、BMI、TC、TG、HDL-C、UA比较差异均无统计学意义(P<0.05)。将上述有统计学意义的变量进行Logistic回归分析，结果显示，年龄、性别、吸烟、高收缩压、高血糖是颈动脉斑块形成的独立危险因素(P<0.05)。结论 颈动脉斑块的形成是多因素共同作用的结果，而年龄、性别、吸烟、高收缩压、高血糖可能是颈动脉斑块形成的独立危险因素，饮酒、糖化血红蛋白、低密度脂蛋白增高是颈动脉斑块形成的相关因素。
      【关键词】 健康人群；颈动脉斑块；高血糖；危险因素
      【中图分类号】 R543.4 【文献标识码】 A 【文章编号】 1003—6350（2017）05—0698—03

Detection rate and risk factors of carotid plaque formation in healthy population.
LU Ji-qiang 1, SHEN Zhen-hai 1,LU Yun 1, QI Hua-jin 1, WANG Ling 1, FAN Chun 1, JIN Yun-fang 2. Department of Ultrasonography 1, Mental Health Center 2,Taihu Rehabilitation Hospital, Wuxi 214000, Jiangsu, CHINA
【Abstract】 Objective To explore the information of carotid artery plaque formation in healthy population, andinvestigate its risk factors, in order to reduce the incidence of cardiovascular events. Methods The clinical data of 1 014cases of carotid artery examination in our hospital from January 2015 to October 2015 were randomly selected and di-vided into the plaque group (98 cases) and non-plaque group (916 cases) according to the examination results. Com-bined with the questionnaire and biochemical indicators of triglyceride (TG), total cholesterol (TC), high density lipo-protein (HDL-C), low density lipoprotein (LDL-C), blood uric acid (UA), fasting blood glucose (FBG), glycosylatedhemoglobin (HbA1c) and other indexes univariate analysis was carried out firstly. Logistic regression analysis wasthen used to analyze the variables associated with carotid plaque formation to obtain the major independent risk fac-tors. Results There were significant differences between the two groups in age, sex, smoking, drinking, blood pressure,FBG, HbA1c, LDL-C (P<0.05). There were no significant differences between the two groups in salt intake, exercise,BMI, TC, TG, HDL-C, UA (P>0.05). Regression analysis showed that age, sex, smoking, high systolic blood pressureand hyperglycemia were the independent risk factors for carotid plaque formation (P<0.05). Conclusion Carotidplaque formation is the result of interaction of multiple factors. Age, sex, smoking, high blood pressure, hyperglycemiamay be independent risk factors for carotid artery plaque formation, while drinking, glycosylated hemoglobin, increaseof low density lipoprotein are the related factors of carotid artery plaque formation.
      【Key words】 Healthy population; Carotid plaque; Hyperglycemia; Risk factors·论 著·doi:10.3969/j.issn.1003-6350.2017.05.004基金项目：江苏省无锡市科技计划项目(编号：CMB21S1301)