标题：血清胱抑素Ｃ、β2微球蛋白对早期糖尿病肾病的诊断价值

      作者：陈树华，袁炜华，江小兰    (云浮市人民医院检验科，广东 云浮 527300)

      卷次： 2018年29卷12期

      【摘要】 目的 探讨血清胱抑素Ｃ(CysC)、β2微球蛋白(β2-MG)在早期２型糖尿病肾病(DN)中的诊断价值。方法 选取2016年10月至2017年10月间云浮市人民医院糖尿病患者140例，根据患者24 h尿微量白蛋白排泄率(UAER)将患者分为临床糖尿病肾病组29例、早期糖尿病肾病组42例和非糖尿病肾病组69例，同期健康体检者40例作为对照组，观察四组受检者CysC、β2-MG、尿素氮(BUN)的变化情况，并采用Pearson相关分析各指标间的相关性。结果 临床糖尿病肾病组患者的CysC、β2-MG和BUN水平明显高于其他三组，早期糖尿病肾病组患者的CysC、β2-MG和BUN水平又明显高于非糖尿病肾病组和对照组，差异均有统计学意义(P<0.05)；临床糖尿病肾病组患者的CysC、β2-MG和BUN的阳性检出率明显高于其他三组，早期糖尿病组患者的CysC、β2-MG检出阳性率明显高于非糖尿病组和正常对照组，差异均有统计学意义(P<0.05)；糖尿病肾病患者的CysC、β2-MG检出阳性率明显高于BUN，差异均有统计学意义(P<0.05)；CysC与β2-MG、BUN呈正相关(r=0.652、0.534，P<0.05)；同样β2-MG与CysC、BUN呈正相关(r=0.652、0.485，P<0.05)。结论 糖尿病肾病患者CysC、β2-MG水平均明显升高，且随着病变程度的加重呈升高趋势。在早期糖尿病肾病诊断中，CysC、β2-MG检出阳性率明显高于BUN，是一种良好的检测指标。
      【关键词】 血清胱抑素C；β2微球蛋白；2型糖尿病；早期糖尿病肾病
      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2018）12—1693—03

Value of serum cystatin C and β 2 microglobulin in the diagnosis of early diabetic nephropathy.
CHEN Shu-hua,YUAN Wei-hua, JIANG Xiao-lan. Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu 527300, Guangdong,CHINA
【Abstract】 Objective To investigate the diagnostic value of serum cystatin C (CysC) and β2 microglobulin(β2-MG) in early type 2 diabetic nephropathy. Methods A total of 140 patients with diabetes, who admitted to Yunfu Peo-ple's Hospital from October 2016 to October 2017, were selected and divided into the clinical diabetic nephropathy group,early diabetic nephropathy group and non-diabetic nephropathy group according to the 24-hour UAER. In the same peri-od, 40 cases of healthy physical examination were enrolled as the control group. The changes of CysC, β 2-MGM, bloodurea nitrogen (BUN) were observed, and the correlation between the four groups were observed. Results CysC, β2-MG,BUN in the clinical diabetic nephropathy group were significantly higher than those of the other three groups, and theCysC, β 2-MG, BUN in the early diabetic nephropathy group were significantly higher than those in the non-diabetic ne-phropathy group and the control group (P<0.05). The positive rate of CysC, β2-MG, BUN in the clinical diabetic nephropa-thy group was significantly higher than that of the other three groups, and the positive rate of CysC, β2-MG in the early di-abetic group was significantly higher than that of non-diabetic nephropathy group and control group (P<0.05). CysC waspositively correlated with β 2-MG and BUN (r=0.652, 0.534, P<0.05); β 2-MG was positively correlated with CysC andBUN (r=0.652, 0.485, P<0.05). Conclusion The levels of CysC and β2-MG are significantly increased in patients withdiabetic nephropathy, and they increase with the severity of the disease. In the early diagnosis of diabetic nephropathy,the positive rate of CysC and β2-MG is significantly higher than that of BUN, which is a good detection index.
      【Key words】 Serum cystatin C (CysC); β 2 microglobulin (β 2-MG); Type 2 diabetes mellitus; Early diabetic ne-phropathy·论 著·doi:10.3969/j.issn.1003-6350.2018.12.020基金项目：广东省云浮市卫生和计划生育局医药卫生类科研项目(编号：2016B12)