标题：多巴胺及其受体在消化系肿瘤中的作用及其研究进展

      作者：李欣 1，2，谢睿 2，3，王乾兴 1    (1.遵义医学院细胞生物学教研室，贵州 遵义 563000；2.贵州省消化疾病研究所，贵州 遵义 563000；3.遵义医学院附属医院消化内科，贵州 遵义 563000)

      卷次： 2018年29卷9期

      【摘要】 多巴胺(DA)作为重要的儿茶酚胺类神经递质，在人类中枢神经系统中发挥着重要的调节作用。多巴胺受体是G蛋白偶联受体家族成员之一，目前发现的有5类，分别为D1R、D2R、D3R、D4R、D5R，而不同的受体发挥的作用也不相同。近年来的研究表明DA及其受体在消化道肿瘤的发生发展中起了重要的作用，本文对DA及其受体对消化道肿瘤的作用做一综述，以期为消化道肿瘤的预后及治疗提供线索。
      【关键词】 多巴胺；多巴胺受体；消化系肿瘤
      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2018）09—1263—04

Research progress of dopamine and its receptors in gastrointestinal cancers' actions and underlying molecularmechanisms.
LI Xin 1,2, XIE Rui 2,3, WANG Qian-xing 1. 1. Department of Cell Biology, Zunyi Medical College, Zunyi563000, Guizhou, CHINA; 2. Institute of Digestive Diseases of Guizhou Province, Zunyi 563000, Guizhou, CHINA; 3.Department of Gastroenterology, the Affiliated Hospital of Zunyi Medical College, Zunyi 563000, Guizhou, CHINA【Abstract】 Dopamine (DA), as an important catecholamine neurotransmitter, plays an significant regulating rolein the human central nervous system. Dopamine receptor is a member of the G protein-coupled receptor family. As sofar, five kinds of dopamine receptors have been confirmed, which are D1R, D2R, D3R, D4R and D5, and the different re-ceptors play different roles. Recent studies have shown that DA and its receptors play an important role in the develop-ment and progression of gastrointestinal cancers. In this paper, the role of DA and its receptors in gastrointestinal cancersis reviewed to provide clues for the prognosis and treatment of gastrointestinal cancers.
      【Key words】 Dopamine (DA); Dopamine receptor; Gastrointestinal cancers·综 述·doi:10.3969/j.issn.1003-6350.2018.09.025基金项目：国家自然科学基金(编号：81660412)；遵义医学院附属医院博士科研启动基金(编号：院字[2015]08号)