标题：促性腺激素释放激素激动剂对早期宫颈癌行保留卵巢根治术患者卵巢功能的保护作用

      作者：李会荣，张同美    (宝鸡市妇幼保健院妇科，陕西 宝鸡 721000)

      卷次： 2018年29卷2期

      【摘要】 目的 探究促性腺激素释放激素激动剂对早期宫颈癌行保留卵巢根治术患者卵巢功能的保护作用。方法 选取宝鸡市妇幼保健院2014年1月至2016年3月期间收治早期宫颈癌患者共80例，采用随机数表法分为对照组和观察组各40例。两组患者均行保留卵巢根治术，术后接受4个疗程PT方案辅助化疗，观察组同时联合促性腺激素释放激素(GnRH)激动剂治疗。比较两组患者化疗前后基础卵泡刺激素(bFSH)水平、血清抗苗勒管激素(AMH)水平、基础雌激素(bE2)水平和基础窦状卵泡数(bAFC)。结果 两组患者化疗前bFSH和bE2水平比较差异均无统计学意义(P>0.05)，化疗后观察组患者bFSH和bE2水平均明显低于对照组[(6.72±2.58) IU/L vs (22.13±6.36) IU/L，(45.87±12.24) pg/mL vs (58.75±17.03) pg/mL]，差异均有统计学意义(P<0.05)；化疗前两组患者AMH水平和bAFC比较差异均无统计学意义(P>0.05)，化疗后观察组患者AMH水平和 bAFC数均明显高于对照组[(2.17±1.47) μg/L vs(0.89±0.59) μg/L，(11.93±3.23)个 vs (3.75±3.01)个]，差异均有统计学意义(P<0.05)。结论 GnRH激动剂可以有效保护早期宫颈癌行保留卵巢根治术患者的卵巢储备功能。
      【关键词】 促性腺激素释放激素；早期宫颈癌；根治术；卵巢功能
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2018）02—0181—03

Protective effects of gonadotropin releasing hormone agonist on ovarian function in patients with early stagecervical cancer undergoing ovarian preservation.
LI Hui-rong, ZHANG Tong-mei. Department of Gynecology, BaojiMaternal and Child Health Hospital, Baoji 721000, Shaanxi, CHINA
【Abstract】 Objective To investigate the protective effect of gonadotropin releasing hormone (GnRH) agoniston ovarian function in patients with early stage cervical cancer undergoing ovarian preservation. Methods A total of 80patients with early cervical cancer in Baoji Maternal and Child Health Hospital from January 2014 to March 2016 were en-rolled. Using random number table method, the patients were divided into control group and observation group, with 40cases in each groups. The two groups were treated with radical operation with ovarian preservation, and the patients re-ceived 4 courses of PT program adjuvant chemotherapy after surgery. At the same time, the observation group was treatedwith GnRH agonist. The levels of basal follicle stimulating hormone (bFSH), serum anti-Mullerian hormone (AMH), basalestrogen (bE2) and basal antral follicle count (bAFC) were compared between the two groups before and after chemothera-py. Results There was no significant difference in bFSH and bE2 levels between the two groups before chemotherapy.After chemotherapy, the levels of bFSH and bE2 in the observation group were significantly lower than those in the con-trol group: (6.72±2.58) IU/L vs (22.13±6.36) IU/L, (45.87±12.24) pg/mL vs (58.75±17.03) pg/mL, P<0.05. There was nosignificant difference in AMH level and bAFC between the two groups before chemotherapy. After chemotherapy, theAMH level and bAFC in the observation group were significantly higher than those in the control group: (2.17±1.47) μg/Lvs (0.89±0.59) μg/L, (11.93±3.23) vs (3.75±3.01), P<0.05. Conclusion GnRH agonists can effectively protect ovarian re-serve function in early cervical cancer patients undergoing radical operation with ovaries reserved. It is worthy of clini-cal application.
      【Key words】 Gonadotropin releasing hormone (GnRH); Early cervical cancer; Radical operation; Ovarian func-tion·论 著·doi:10.3969/j.issn.1003-6350.2018.02.010