标题：B超引导下注入聚桂醇对单纯性肾囊肿患者应激相关指标的影响

      作者：吴智慧 1，唐小铁 1，王艳娥 1，宁勇 2    (1.武汉科技大学附属医院武汉市普仁医院肾内科，湖北 武汉 430081；2.华中科技大学同济医学院附属同济医院肾内科血液净化中心，湖北 武汉 430060)

      卷次： 2018年29卷2期

      【摘要】 目的 探讨B超引导下注入聚桂醇对单纯性肾囊肿患者应激相关指标的影响。方法 将2014年 11月至2015年 11月武汉科技大学附属医院收治的单纯性肾囊肿患者86例按随机数表法分为观察组与对照组各43例，对照组采用无水乙醇为硬化剂，观察组采用聚桂醇为硬化剂，比较两组围术期应激相关指标、临床疗效及不良反应。结果 两组患者术后 12 h各应激指标水平除舒张压外均明显高于其余各时段的检测水平，且差异有统计学意义(P<0.05)。其中观察组术后48 h血清应激指标血清皮质醇(Cor) [(201.22±16.27) ng/mL vs (199.58±23.47) ng/mL]、肾上腺素(AD) [(0.14±0.05) ng/mL vs (0.14±0.03) ng/mL]、去甲肾上腺素(NE) [(267.09±20.54) ng/mL vs (262.17±19.98) ng/mL]及血管紧张素Ang-Ⅱ[(51.34±6.84) pg/mL vs (49.99±6.78) pg/mL]及体征应激指标体温[(36.2±0.4)℃ vs (36.3±0.2)℃]、收缩压[(121.6±13.8) mmHg vs (120.3±14.5) mmHg]及血糖[(5.2±0.9) mmol/L vs (4.9±0.7) mmol/L]与术前水平比较差异均无统计学意义(P<0.05)。对照组术后 72 h血清应激指标Cor [(203.22±18.01) ng/mL vs (201.47±20.13) ng/mL]、AD[(0.15±0.04) ng/mL vs (0.15±0.03) ng/mL]、NE [(267.10±21.45) ng/mL vs (264.54±21.38) ng/mL]及 Ang-Ⅱ[(49.86±6.25) pg/mL vs (50.65±5.67) pg/mL]及体征应激指标体温[(36.2±0.1)℃ vs (36.2±0.3)℃]、收缩压[(122.9±13.2) mmHgvs (123.4±11.3) mmHg]及血糖[(5.2±0.8) mmol/L vs (5.1±0.6) mmol/L]与术前水平比较差异均无统计学意义(P>0.05)。观察组患者临床治疗的总有效率为 93.0%，明显高于对照组的69.8%，差异有统计学意义(P<0.05)；观察组发生过敏及血尿例数与对照组比较差异无统计学意义(P>0.05)，而观察组出现腰部酸胀(4.7%)及发热(2.3%)的比例明显低于对照组(20.9%、25.6%)，且差异具有统计学意义(P<0.05)。结论 采用聚桂醇为硬化剂对单纯性肾囊肿患者进行B超引导治疗，不仅能够对各应激指标有调节作用，同时能提高疗效，降低不良反应发生率。
      【关键词】 B超引导；硬化剂；聚桂醇；肾囊肿；应激
      【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350（2018）02—0170—04

Influence of ultrasound-guided injection of lauromacrogol on the stress response of patients with simple renalcyst.
WU Zhi-hui 1, TANG Xiao-tie 1, WANG Yan-e 1, NING Yong 2. 1. Department of Nephrology, the Affiliated Hospital ofWuhan University of Science and Technology, Wuhan Puren Hospital, Wuhan 430081, Hubei, CHINA; 2. Blood PurificationCenter, Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science andTechnology, Wuhan 430060, Hubei, CHINA
【Abstract】 Objective To study the influence of ultrasound-guided injection of lauromacrogol on the stress re-sponse of patients with simple renal cyst. Methods Eighty-six patients with simple renal cyst from November 2014 to No-vember 2015 in our hospital divided into observation group (n=43) and control group (n=43), which received lauromacro-gol and absolute ethyl alcohol as sclerosis, respectively. The stress response indexes, clinical effect and side effect in of twogroups were compared. Results The levels of stress response indexes (except diastolic pressure) 12 h after operation were·论 著·doi:10.3969/j.issn.1003-6350.2018.02.007基金项目：湖北省自然科学基金项目(编号：2014CFB964)