标题：N-乙酰半胱氨酸辅助治疗AECOPD的疗效及其对患者血清CRP的影响

      作者：宁晶娜 1，吴艳玲 2，欧阳卿 2    (深圳市宝安区石岩人民医院内一科 1、内二科 2 广东 深圳 518108)

      卷次： 2017年28卷9期

      【摘要】 目的 探讨N-乙酰半胱氨酸辅助治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效及其对患者血清C反应蛋白(CRP)的影响。方法 选择我院内一科于2014年10月至2016年6月间收治的AECOPD患者86例为研究对象，根据随机数字表法随机分为观察组(n=43)与对照组(n=43)，对照组患者予抗感染等常规治疗，观察组在此基础上加用乙酰半胱氨酸颗粒治疗，疗程2周。比较两组患者临床疗效及治疗前后血清CRP的变化。结果 观察组的治疗总有效率为93.02%，明显高于对照组的79.07%，差异有统计学意义(P<0.05)；观察组与对照组治疗后血清CRP水平为(8.69±3.94) mg/L、(14.28±5.86) mg/L，明显低于治疗前的(21.52±8.33) mg/L、(20.65±7.26) mg/L，且观察组明显低于对照组，差异均有统计学意义(P<0.05)。结论 N-乙酰半胱氨酸辅助治疗慢性阻塞性肺疾病急性加重期患者可降低血清CRP水平，提高临床疗效。
      【关键词】 慢性阻塞性肺疾病；N-乙酰半胱氨酸；C反应蛋白；疗效
      【中图分类号】 R563 【文献标识码】 A 【文章编号】 1003—6350（2017）09—1409—02

Effect of supplementary treatment of N-Acetyl-L-cysteine on patients with acute exacerbation of chronicobstructive pulmonary disease and its effect on serum C-reactive protein.
NING Jing-na 1, WU Yan-ling 2, OUYANGQing 2. First Department of Internal Medicine 1, Second Department of Internal Medicine 2, Shiyan People's Hospital of BaoanDistrict of Shenzhen, Shenzhen 518108, Guangdong, CHINA
【Abstract】 Objective To investigate the effect of N-Acetyl-L-cysteine treatment on patients with acute exacerba-tion of chronic obstructive pulmonary disease (AECOPD) and its effect on serum C-reactive protein (CRP). Methods Atotal of 86 patients with AECOPD treated in First Department of Internal Medicine, Shiyan People's Hospital of BaoanDistrict of Shenzhen from October 2014 to June 2016 were divided into observation group (n=43) and control group (n=43) according to randomly number method. The control group was treated with anti-infective therapy, and the observationgroup was treated with N-Acetyl-L-cysteine plus anti-infective therapy, both for two weeks. The clinical efficacy andchanges of serum CRP between the two groups before and after treatment were compared. Results After treatment, thetotal effective rate in the observation group was 93.02%, which was significantly higher than that in the control group(79.07%), showing significant difference (P<0.05). After treatment, the serum CRP in the observation group and controlgroup was (8.69±3.94) mg/L and (14.28±5.86) mg/L, which was significantly lower than (21.52±8.33) mg/L and (20.65±7.26) mg/L before treatment, and the serum CRP in the observation group was significantly lower than that in the controlgroup (P<0.05). Conclusion The application of N-Acetyl-L-cysteine in the treatment of acute exacerbation of chronicobstructive pulmonary disease can reduce the level of serum CRP and improve the clinical efficacy.
      【Key words】 Chronic obstructive pulmonary disease; N-Acetyl-L-cysteine; C-reactive protein; Therapeutic effect·论 著·doi:10.3969/j.issn.1003-6350.2017.09.011