标题：Graves病及桥本病患者血硒、GSH-Px及甲状腺素水平分析

      作者：叶冠伦 1，郑伟明 2，罗卓章 1
    (佛山市南海区第二人民医院内分泌科 1、检验科 2，广东 佛山 528200)

      卷次： 2016年27卷14期

      【摘要】 目的 比较Graves病及桥本病(HHD)患者血硒、谷胱甘肽过氧化物酶(GSH-Px)及甲状腺素水平。
方法 选择我院2014年9月至2015年9月Graves病患者30例作为Graves病组，HD患者30例作为HD组，另选择
健康人30例作为对照组，测定和分析三组受检者的血硒、GSH-Px、促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离
三碘甲状腺原氨酸(FT3)、甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)、甲状腺 TSH受体抗体
(TRAb)水平。结果 Graves病组和 HD组的硒、GSH-Px分别为 (102.37±3.59 ) μg/L、(108.25±4.25) μg/L以及
(212.75±53.26) U/L、(214.24±53.16) U/L，明显低于对照组的(126.96±5.68) μg/L、(390.45±84.63) U/L，差异均有统计
学意义 (P<0.05)；而 TRAb、TPO-Ab、TG-Ab分别为 (54.24 ± 11.32) IU/mL、(49.82 ± 9.32) IU/L、(53.44 ± 12.34)%和
(51.62±12.91) IU/mL、(42.24±8.43) IU/L、(50.57±10.23)%，明显高于对照组的(9.25±3.16) IU/mL、(3.24±1.01) IU/L、
(15.45±2.33)%，差异均具有统计学意义(P<0.05)；Graves病组与HD组以上各项指标比较差异均无统计学意义
(P>0.05)。血硒与TPO-Ab、TRAb、TG-Ab呈负相关(P<0.05)，GSH-Px与TPO-Ab、TRAb、TG-Ab呈负相关(P<0.05)。
结论 Graves病及桥本病患者的血硒水平偏低，可能影响机体甲状腺激素的正常合成，患者通过补硒可能有利
于疾病的好转。

      【关键词】 Graves病；桥本病；硒；谷胱甘肽过氧化物酶

      【中图分类号】 R582+.1 【文献标识码】 A 【文章编号】 1003—6350（2016）14—2292—03


Analysis of blood selenium, GSH-Px and thyroid hormone level in patients with Graves disease and Hashimoto's
disease.
YE Guan-lun 1, ZHENG Wei-ming 2, LUO Zhuo-zhang 1. Department of Endocrinology 1, Department of Medical
Laboratory 2, the Second People's Hospital of Nanhai District, Foshan City, Foshan 528200, Guangdong, CHINA

【Abstract】 Objective To compare the blood selenium, glutathione peroxidase (GSH-Px) and thyroid hormone
levels in patients with Graves disease and Hashimoto's disease (HD). Methods Thirty patients with Graves disease in
our hospital from Sep. 2014 to Sep. 2015 were choose as the Graves group, and thirty patients of HD were selected as the
HD group. A the same time, 30 healthy people were enrolled as the control group. The blood selenium, GSH Px, thyroid
stimulating hormone (TSH), free thyroxine (FT4), free three iodine thyroid original ammonia acid (FT3), thyroid peroxidase
antibody (TPOAb), thyroglobulin antibody (TG-Ab), thyroid TSH receptor antibody (TRAb) levels were measured and
analyzed. Results The levels of selenium, GSH-Px in Graves group and HD group were (102.37±3.59) μg/L, (108.25±
4.25) μg/L, (212.75 ± 53.26) μg/L, (214.24 ± 53.16) μg/L, which were significantly lower than those in control group
[(126.96±5.68) μg/L, (390.45±84.63) U/L, P<0.05]. The levels of TRAb, TPO-Ab, TG-Ab in Graves group and HD group
were (54.24±11.32) IU/mL, (49.82±9.32) IU/L, (53.44±12.34)% and (51.62±12.91) IU/mL, (42.24±8.43) IU/L,
(50.57 ± 10.23)% , which were significantly higher than those in control group [(9.25 ± 3.16) IU/mL, (3.24 ± 1.01) IU/L,
(15.45±2.33)%, P<0.05]. There was no significant difference between the indexes of Graves group and HD group (P>
0.05). Blood selenium was negatively correlated with TPO-Ab, TRAb, and TG-Ab (P<0.05). GSH-Px was negatively
correlated with TPO-Ab, TRAb and TG-Ab (P<0.05). Conclusion The selenium level of Graves disease and HD pa-
tients were significantly lower than healthy people, which may influence the synthesis of thyroid hormone. Therefore, se-
lenium may be beneficial for patients to improve the disease condition.

      【Key words】 Graves disease; Hashimoto's disease (HD); Selenium; Glutathione peroxidase (GSH-Px)
·论 著·
6350.2016.14.019