标题：胃癌患者组织p-mTOR的阳性表达与临床病理参数及预后的相关性

      作者：王静 1，王亚明 2，霍双 3，吴士茜 1，孙颖 1，袁艳龙 1，王杰 4，田云霄 1，张桂东 2，刘博 5    (邯郸市中心医院病理科 1、普外科 2、科教科 3、泌尿外科 4、急诊外科 5，河北 邯郸 056001)

      卷次： 2017年28卷2期

      【摘要】 目的 探讨胃癌患者组织磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)的阳性表达与临床病理参数及预后的相关性。方法 于2013年1月至12月对邯郸市中心医院收治的89例胃癌患者采用免疫组化法检测胃组织标本中 p-mTOR的表达，分析其与淋巴结转移、浸润深度、组织分化程度和病理分期的相关性，并按 p-mTOR的不同表达情况比较患者的预后。结果 p-mTOR阳性率为77.53% (69/89)，其中有淋巴结转移的患者p-mTOR阳性率为 90.20%，高于无淋巴结转移者的 60.53%，差异有统计学意义(P<0.05)；Spearman等级相关分析显示，p-mTOR的阳性表达与浸润深度、组织分化及肿瘤分期均呈正相关(P<0.01)，相关系数分别为 0.65、0.69和 0.64。p-mTOR低表达组的疾病无进展中位生存期为23.5个月，显著长于高表达组的12.8个月，差异有显著统计学意义(P<0.01)。结论 p-mTOR在胃癌患者体内高表达，检测p-mTOR的表达有利于患者的预后评估。
      【关键词】 胃癌；磷酸化哺乳动物雷帕霉素靶蛋白；免疫组化；预后；相关性
      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350（2017）02—0188—04

Correlation of positive expression of p-mTOR with clinicopathological factors and prognosis in gastric cancerpatients.
WANG Jing 1, WANG Ya-ming 2, HUO Shuang 3, WU Shi-xi 1, SUN Ying 1, YUAN Yan-long 1, WANG Jie 4, TIANYun-xiao 1, ZHANG Gui-dong 2, LIU Bo 5. Department of Pathology 1, Department of General Surgery 2, Department ofScience and Education 3, Department of Urinary Surgery 4, Department of Emergency Surgery 5, Handan Municipal CentralHospital, Handan 056001, Hebei, CHINA
【Abstract】 Objective To analyze the correlation of positive expression of phosphorylated mammalian target ofraphmycin (p-mTOR) with clinicopathological factors and prognosis in gastric cancer patients. Methods The expres-sion of p-mTOR of stomach tissue specimens from 89 gastric cancer patients in Handan Municipal Central Hospital fromJan. 2013 to Dec. 2013 were detected by immunohistochemistry method, and its correlation with lymphatic metastasis,depth of invasion, degree of differentiation and pathological stage were analyzed. The relationship of p-mTOR with prog-nosis of patients was assessed according to the expression level of p-mTOR. Results The positive rate of p-mTOR was77.53% (69/89). The positive rate of p-mTOR in patients with lymphatic metastasis was 90.20%, higher than that of pa-tients without lymphatic metastasis (60.53%), and difference was statistically significant (P<0.05). The Spearman rank cor-relation showed that positive expression of p-mTOR had positive correlation with depth of invasion, degree of differentia-tion and pathological stage (all P<0.01), with correlation coefficient of 0.65, 0.69, and 0.64 respectively. The median pro-gression free survival in group of low p-mTOR expressing was 23.5 months, longer than that of group of high p-mTOR ex-pressing which was 12.8 months, and the difference was statistically significant (P<0.01). Conclusion There is high ex-pression of p-mTOR in gastric cancer patients, and the detection of p-mTOR is in favor of assessment of prognosis.
      【Key words】 Gastric cancer; p-mTOR; Immunohistochemistry; Prognosis; Correlation·论 著·doi:10.3969/j.issn.1003-6350.2017.02.006