标题：IL-6和STAT3在结肠癌组织中的表达及意义

      作者：张晓芹，段丽芳，党琳，许小凡，张红    (陕西中医药大学病理生理学教研室，陕西 咸阳 712046)

      卷次： 2017年28卷2期

      【摘要】 目的 检测白介素6 (IL-6)和信号转导及转录激活因子3 (STAT3)在结肠癌和癌旁组织中的表达及其在结肠癌诊治中的临床意义。方法 收集陕西中医药大学第二附属医院2012年3月至2014年12月经病理学诊断的48例结肠癌患者的手术标本，采用免疫组织化学法检测癌及癌旁组织中 IL-6和STAT3的表达，分析两者表达的相关性。结果 结肠癌组织中 IL-6的阳性表达率为91.66%，而癌旁组织阳性表达率仅6.25%，两者比较差异有显著统计学意义(P<0.01)；结肠癌组织中STAT3的阳性表达率为95.83%，也明显高于癌旁组织的4.17%，差异有统计学意义(P<0.05)；结肠癌组织中STAT3与 IL-6的表达呈正相关(r=0.765，P<0.01)。结论 IL-6和STAT3参与结肠癌的发生发展，并可作为结肠癌诊断的重要参考及治疗的靶点。
      【关键词】 结肠癌；白介素6；信号转导及转录激活因子3
      【中图分类号】 R735.3+5 【文献标识码】 A 【文章编号】 1003—6350（2017）02—0185—03

Expression and significance of IL-6, STAT3 in colon carcinoma tissue.
ZHANG Xiao-qin, DUAN Li-fang, DANG Lin,XU Xiao-fan, ZHANG Hong. Department of Pathophysiology, Shaanxi University of Chinese Medicine, Xianyang 712046,Shaanxi, CHINA
【Abstract】 Objective To detect the expression of interlenkin-6 (IL-6) and signal transducer and activator oftranscription 3 (STAT3) in colon carcinoma tissue and paracancerous tissue, and to analyze its clinical significance in thediagnosis and treatment of colon carcinoma. Methods Forty-eight samples of colon carcinoma confirmed by pathologyin the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from March 2012 to December 2014 werecollected. The expression of IL-6 and STAT3 in colon cancer tissue and paracancerous tissue were detected by immuno-histochemistry. The correlation between the two were analyzed. Results The positive expression rate of IL-6 in coloncarcinoma tissue was 91.66%, which was higher than that in paracancerous tissue of 6.25% (P<0.01). The positive ex-pression rate of STAT3 in colon carcinoma tissue was 95.83%, which was significantly higher than that in paracancer-ous tissue of 4.17% (P<0.05). The expression of STAT3 was positively correlated with IL-6 in colon carcinoma tissue.Conclusion IL-6 and STAT3 are involved in the occurrence and development of colon carcinoma, which can be usedas an important reference for colon carcinoma diagnosis and therapeutic targets.
      【Key words】 Colon carcinoma; Interlenkin-6 (IL-6); Signal transducer and activator of transcription 3 (STAT3)·论 著·doi:10.3969/j.issn.1003-6350.2017.02.005基金项目：陕西中医药大学培育基金(编号：2016PY09)