标题：苦参对抗甲状腺药物致Graves病患者白细胞减少的影响

      作者：汤建雷 1，周彦 2，高云明 1
    (连云港市第二人民医院内分泌科 1、检验科 2，江苏 连云港 222000)

      卷次： 2016年27卷14期

      【摘要】 目的 针对Graves病(GD)经抗甲状腺药物(ATD)治疗后出现白细胞减少患者，通过苦参治疗后观察
疗效，并初步探讨其可能的作用机制。方法 随机选取2014年1月至2015年10月我科收治的ATD致白细胞减少
的GD患者共计 30例作为研究对象，检测记录患者外周血白细胞(WBC)、粒细胞(NE)数量，及血清白细胞介素-1
(IL-1)、白细胞介素-6 (IL-6)含量，随后患者在继续ATD治疗同时联合苦参应用，10 d后再次检测外周血WBC、NE
数量及血清中 IL-1、IL-6含量。结果 GD患者ATD治疗后外周血WBC、NE数量、血清 IL-1、IL-6含量分别为
(3.45±0.25)×109/L、(1.72±0.21)×109/L、(0.29±0.06) ng/mL、(1.40±0.14) ng/mL，联合苦参治疗后患者外周血WBC、NE
数量、血清 IL-1、IL-6含量分别为(4.31±0.38)×109/L、(2.34±0.28)×109/L、(0.40±0.07) ng/mL、(1.67±0.08) ng/mL，差异
均具有统计学意义(P<0.05或 0.01)。血清 IL-1、IL-6水平与外周血WBC、NE数量呈直线正相关(r=0.595，0.456；
0.473，0.467，P<0.05或0.01)。结论 苦参对ATD致GD白细胞减少患者的治疗能明显提升其WBC和NE数量，究
其原因可能是通过促进体内免疫细胞因子 IL-1、IL-6的表达进而刺激患者骨髓造血从而达到治疗效果。

      【关键词】 苦参；白细胞减少；Graves病；抗甲状腺药物；细胞因子

      【中图分类号】 R582+.1 【文献标识码】 A 【文章编号】 1003—6350（2016)14—2277—03


Effects of Sophora flavescens on Graves' disease patients with leucopenia induced by anti-thyroid drug.
TANG
Jian-lei 1, ZHOU Yan 2, GAO Yun-ming 1. Department of Endocrinology 1, Department of Clinical Laboratory 2, the Second
People's Hospital of Lianyungang City, Lianyungang 222000, Jiangsu, CHINA

【Abstract】 Objective To observe the therapeutic effect of Sophora flavescens on Graves' disease (GD) patients
with leucopenia after treatment of anti-thyroid drug (ATD), and to make a preliminary discussion on the possible mech-
anism of its formation. Methods Thirty GD patients with leucopenia after ATD treatment from January 2014 to Octo-
ber 2015 in our department were randomly chosen to detect peripheral white blood cell (WBC), neutrophilic granulo-
cyte (NE) counts and blood serum interleukin 1 (IL-1), interleukin 6 (IL-6) levels. After that, these patients were treat-
ed with Sophora flavescens and ATD for ten days, and WBC, NE counts, IL-1, IL-6 levels would be again checked out.
Results After ATD treatment, peripheral WBC, NE counts and blood serum IL-1, IL-6 levels were (3.45±0.25)×109/L,
(1.72±0.21)×109/L, (0.29±0.06) ng/mL, (1.40±0.14) ng/mL, respectively. After Sophora flavescens and ATD treatment,
above indexes were (4.31±0.38)×109/L, (2.34±0.28)×109/L, (0.40±0.07) ng/mL, (1.67±0.08) ng/mL, respectively. The dif-
ference of each index showed statistical significance (P<0.05 or 0.01). Then, we found there was a positive correlation
between IL-1, IL-6 levels and WBC, NE counts (r=0.595, 0.456; 0.473, 0.467, P<0.05 or 0.01 for all). Conclusion Af-
ter ATD treatment, WBC and NE counts of partial patients decreased, while Sophora flavescens would obviously elevate
WBC and NE counts of GD patients with leucopenia. The possible mechanism of its formation is that Sophora flavescens
promote IL-1, IL-6 levels of these patients to stimulate the proliferation and differentiation of blood cells in the bone
marrow.

      【Key words】 Sphora flavescens; Leukopenia; Graves' disease (GD); Anti-thyroid drug (ATD); Cytokine
·论 著·
6350.2016.14.014