标题：VPS35基因和帕金森病

      作者：乔科平 1，李红燕 2    (1.新疆医科大学研究生学院，新疆 乌鲁木齐 830001；2.新疆维吾尔自治区人民医院神经内科，新疆 乌鲁木齐 830001)

      卷次： 2016年27卷23期

      【摘要】 帕金森病(PD)是一种严重威胁中老年人健康和生活质量的神经功能障碍性疾病。该病的发病原因和确切的发病机制仍不清楚。多数研究认为PD是由遗传易感性和环境因素共同作用的多基因疾病。最近，与迟发性常染色体显性遗传帕金森病相关的液泡分拣蛋白35同源基因(VPS35)为PD的发病机制提供了新的线索。对VPS35基因的研究将有助于该病的基因诊断、病理生理学机制的阐明和治疗。
      【关键词】 帕金森病；VPS35基因；基因诊断；病理生理学机制
      【中图分类号】 R742.5 【文献标识码】 A 【文章编号】 1003—6350（2016）23—3883—04

VPS35 gene and Parkinson's disease.
QIAO Ke-Ping 1, LI Hong-Yan 2. 1. Postgraduate College of Xinjiang MedicalUniversity, Urumchi 830001, Xinjiang, CHINA; 2. Department of Neurology, Xinjiang Uygur Autonomous Region people'sHospital, Urumchi 830001, Xinjiang, CHINA【Abstract】 Parkinsion's disease is a nerve dysfunction disease which seriously threatens the health and quality oflife of the elderly. The etiology of the disease and the exact pathogenesis are remains unclear. Most studies suggest that-PD is known as a polygenetic disease in which genetic susceptibility and environmental factors may play importantroles. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35) is related to the late onset au-tosomal dominant genetic disease, which provides a new clue for the pathogenesis of PD. Study of VPS35 gene will behelpful for gene diagnosis, elucidation of pathophysiologic mechanism and treatment of Parkinson's disease.
      【Key words】 Parkinson's disease; Vacuolar protein sorting 35 homolog gene (VPS35) gene; Gene diagnosis;Pathophysiologic mechanism·综 述·doi:10.3969/j.issn.1003-6350.2016.23.032基金项目：国家自然科学基金(编号：31560270)