标题：抗病毒治疗对艾滋病感染者CD4+T淋巴细胞计数的影响

      作者：欧慧 1，高赛珍 1，王曼 2，黄宗杰 1    (中山市疾控预防控制中心检验科 1、防疫科 2，广东 中山 528400)

      卷次： 2016年27卷22期

      【摘要】 目的 探讨抗病毒治疗对艾滋病感染者CD4+T淋巴细胞计数的影响。方法 选择 2014年 1月至2015年6月期间中山市疾病预防控制中心确诊的92例艾滋病患者，均接受高效抗逆转录病毒疗法(HAART)治疗，记录治疗前及治疗3个月、6个月时患者血CD4+T淋巴细胞计数的变化，分析影响CD4+T淋巴细胞计数增加量的相关因素。结果 HAART治疗3个月后，患者血CD4+T淋巴细胞计数出现上升者占88.04%；治疗6个月后，所有患者CD4+T淋巴细胞计数均有不同程度的上升，CD4+T淋巴细胞计数增加量在年龄<40岁、治疗前CD4+T淋巴细胞计数≥200、BMI≥23及无药物漏服的患者中明显高于年龄≥40岁、治疗前CD4+T淋巴细胞计数<200、BMI<23及有药物漏服者，差异均有统计学意义(P<0.05)。结论 高效抗逆转录病毒疗法可显著增加艾滋病患者外周血CD4+T淋巴细胞计数，其疗效与年龄、治疗时机、BMI及用药依从性有关。
      【关键词】 艾滋病；人类免疫缺陷病毒；高效抗逆转录病毒疗法；免疫
      【中图分类号】 R512.91 【文献标识码】 A 【文章编号】 1003—6350（2016）22—3654—02

Effect of antiviral therapy on CD4+ T lymphocyte count in AIDS patients.
OU Hui 1, GAO Sai-zhen 1, WANG Man 2,HUANG Zong-jie 1. Department of Inspection 1, Department of Epidemic Prevention 2, Zhongshan Center for Disease Controland Prevention, Zhongshan 528400, Guangdong, CHINA
【Abstract】 Objective To investigate the effect of antiviral therapy on CD4+ T lymphocyte count and its relatedfactors in acquired immune deficiency syndrome (AIDS) patients. Methods Ninety-two AIDS patients diagnosed inZhongshan Center for Disease Control and Prevention from January 2014 to June 2015 treated by anti-retroviral therapy(HAART) were studied. Before treatment and three and six months after treatment, changes of CD4 + T lymphocytecounts were recorded. The related factors of CD4+ T lymphocyte count increase were analyzed. Results After 3 monthsof HAART treatment, the proportion of patients with increased CD4+ T lymphocyte count was 88.04%. After 6 monthsof treatment, CD4+ T lymphocyte count in all patients had varying degrees of increase. The increase in patients with age<40 years, CD4+ T lymphocyte count≥200 before treatment, BMI≥23 and no medication mistakes was more significantthan that of the patients with age≥40 years, CD4+ T lymphocyte count<200 before treatment, BMI<23 and medicationmistakes (P<0.05). Conclusion HAART can significantly increase the CD4+ T lymphocyte count in AIDS patients, andthe therapeutic effect is related to age, timing of treatment, BMI and medication compliance.
      【Key words】 Acquired immune deficiency syndrome (AIDS); Human immunodeficiency virus; Anti-retroviraltherapy; Immunity·论 著·doi:10.3969/j.issn.1003-6350.2016.22.014基金项目：广东省中山市科技计划项目(编号：2014A1FC191)