标题：β-七叶皂苷钠治疗急性脑梗死的疗效及其对患者血清白细胞介素-6的影响

      作者：黄佐才 1，徐招柱 2，石佳泉 1，凌维汉 2，林贤昌 1    (梅州市人民医院急诊医学科 1、神经内科 2，广东 梅州 514011)

      卷次： 2016年27卷21期

      【摘要】 目的 探讨β-七叶皂苷钠治疗急性脑梗死的疗效及其对患者血清白细胞介素-6的影响。方法 选取2014年12月至2015年12月我院收治的286例急性脑梗死患者，采用简单随机分组法分为观察组和对照组，每组143例。对照组采用常规对症治疗，观察组在此基础上加用β-七叶皂苷钠，剂量为20 mg/d，连用两周。比较两组患者治疗后的临床症状、治疗前后的神经损伤程度和血清中 IL-6水平。结果 治疗两周后，观察组患者的总有效率为 86.71% (124/143)，明显高于对照组的 60.84% (87/143)，差异有统计学意义(P<0.05)；治疗前两组患者的神经损伤和血清 IL-6水平比较差异无统计学意义(P>0.05)；治疗后 24 h，观察组患者的神经损伤程度评分降低至(30.36±5.19)分，与对照组的(29.82±4.83)分比较差异仍无统计学意义(P>0.05)；治疗后7 d、14 d和30 d，观察组患者的神经损伤评分分别为(25.82±4.37)分、(22.06±4.06)分和(16.52±4.26)分，呈现逐渐减轻的趋势，其分别与对照组的(27.52±4.79)分、(24.78±3.88)分和(20.07±3.79)分比较差异均有统计学意义(P<0.05)；观察组患者的血清 IL-6水平从治疗后 24 h开始到治疗后 30 d分别为(247.16±42.31) pg/mL、(207.19±37.58) pg/mL、(172.36±39.27) pg/mL和(169.54±40.34) pg/mL，亦呈现逐渐下降的趋势，且在各时间点均低于对照组的(250.94±46.49) pg/mL、(236.82±39.05) pg/mL、(214.38±40.15) pg/mL、(207.83± 36.21) pg/mL，但从治疗后 7 d开始两组间比较差异均有统计学意义(P<0.05)。结论 ?β-七叶皂苷钠能够有效降低急性脑梗死患者血清中的 IL-6，明显改善神经损伤。
      【关键词】 β-七叶皂苷钠；急性脑梗死；白细胞介素-6；疗效
      【中图分类号】 R743.33 【文献标识码】 A 【文章编号】 1003—6350（2016）21—3479—03

Effects of β-sodium aescinate on the serum levels of IL-6 in patients with acute cerebral infraction.
HUANGZUO-cai 1, XU ZHAO-zhu 2, SHI JIA-quan 1, LING WEI-han 2, LIN XIAN-chang 1. Department of Emergency Medicine 1,Department of Neurology 2, the People's Hospital of Meizhou, Meizhou 514011, Guangdong, CHINA
【Abstract】 Objective To explore the effects of β-sodium aescinate on the serum levels of interleukin-6 (IL-6)in patients with acute cerebral infraction. Methods A total of 286 patients with acute cerebral infraction who receivetreatment in our hospital from Dec. 2014 to Dec. 2015 were involved in this study and divided into two groups randomlyby simple randomization: the treatment group and control group, each of which contained 143 patients. The controlgroup was treated with conventional symptomatic treatment, which on basis the treatment group was treated with β-sodi-um aescinate at a dose of 20 mg/d, for two consecutive weeks. The clinical symptoms, neurological damage and serumlevels of IL-6 of two groups before and after treatment were compared. Results After two weeks of treatment, the to-tal effective rate of treatment group was 86.71% (124/143), which was significantly higher than that of the controlgroup of 60.84% (87/143), P<0.05. The neurological damage and serum IL-6 of the two groups showed no significantdifference before treatment. 24 h after treatment, neurological damage degree of the treatment group reduced to(30.36±5.19), which had no statistical significant difference with that of the control group of (29.82±4.83), P>0.05.Seven days, 14 days, 30 days after treatment, neurological damage of the observation group were (25.82 ± 4.37),(22.06±4.06) and (16.52±4.26), which reduced gradually, and there were significant difference between the treatmentgroup and control group of (27.52±4.79), (24.78±3.88), (20.07±3.79), P<0.05. Serum levels of IL-6 of the treatmentgroup from 24 h to 30 days after treatment were (247.16±42.31) pg/mL, (207.19±37.58) pg/mL, (172.36±39.27) pg/mLand (169.54±40.34) pg/mL, which showed a trend of gradual decline, and they were lower than those of the control groupat various time points of (250.94±46.49) pg/mL, (236.82±39.05) pg/mL, (214.38±40.15) pg/mL, (207.83±36.21) pg/mL,with significant difference 7 days after treatment between the two groups (P<0.05). Conclusion The β-sodium aescinatecan reduce the serum IL-6 of patients with acute cerebral infarction and improve their neurological function effectively.
      【Key words】 ?β-sodium aescinate; Acute cerebral infarction; IL-6; Curative effect·论 著·doi:10.3969/j.issn.1003-6350.2016.21.012