标题：骨钙素在糖代谢中的研究进展

      作者：杨焱平，封启明
    (上海交通大学附属第六人民医院急诊医学科，上海 200233)

      卷次： 2016年27卷19期

      【摘要】 骨钙素（Osteocalcin，OC）是成骨细胞分泌并沉积在骨基质中的非胶原蛋白，参与骨的矿化。糖代谢
可以影响成骨细胞活性，最近研究发现羧化不全骨钙素(uncarboxylatedostecalcin，ucOC）可以促进小鼠胰岛β细胞
增殖，胰岛素分泌，增强胰岛素敏感性，进而调控血糖。在糖尿病人群中也发现骨钙素含量与血糖、胰岛素抵抗等
存在相关性，这将有助于在控制血糖领域的研究。

      【关键词】 骨钙素；血糖；胰岛素；胰岛素受体

      【中图分类号】 R589.1 【文献标识码】 A 【文章编号】 1003—6350（2016）19—3204—03


Research progress of osteocalcin in glucose metabolism.
YANG Yan-ping, FENG Qi-ming. Department of Emergency
Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, CHINA
【Abstract】 Osteocalcin (OC), secreted by osteoblasts, is a non-collagen protein and deposits in bone matrix, af-
fecting bone mineralization. Glucose metabolism can affect osteoblast function. Recent studies have shown that uncar-
boxylatedostecalcin (ucOC) can promote mouse islet beta cells proliferation and insulin secretion, increase insulin sensi-
tivity and control blood glucose. The findings of the correlations between osteocalcin content and glucose, insulin resis-
tance in patients with type 2 diabetes mellitus (T2DM) would contribute to the control of blood glucose.

      【Key words】 Osteocalcin; Blood glucose; Insulin; Insulin receptor
·综 述·doi:10.3969/j.issn.1003-6350.2016.19.036