标题：妊娠前空腹血糖、体质量对妊娠糖尿病患者发病的预测效果

      作者：刘晓丹，徐静
    (聊城市第二人民医院产科，山东 聊城 252600)

      卷次： 2016年27卷19期

      【摘要】 目的 探讨孕前空腹血糖(FPG)及体质量指数(BMI)对妊娠糖尿病的预测价值，为妊娠期糖尿病(GDM)
的早期预防提供依据。方法 选取2013年5月至2014年12月于我院行孕前健康体检并在妊娠后于我院进行产前检
查的385例孕妇，均于孕24~28周行糖耐量试验(OGTT)。采用Logstic回归分析与GDM发生相关的危险因素，采用
ROC曲线分析孕前FPD及BMI对GDM发生的预测价值。结果 385例孕妇中73例发生GDM，发生率为18.96%。根
据孕妇是否发生GDM将其分为GDM组及对照组，GDM组孕妇的年龄、孕前FPG、BMI、收缩压及糖尿病家族史的比例
均高于对照组，差异均有统计学意义(P<0.05)。Logistic回归分析结果显示：年龄、孕前FPG、孕前BMI及糖尿病家族史
是孕妇发生GDM的危险因素。对孕前FPG及BMI的预测价值分析显示：FPG为4.6~4.8 mmol/L时灵敏度为67.12%，
特异度为63.46%；BMI值为23.0~25.0 kg/m2时其预测灵敏度为58.90%，特异度为59.62%。孕前FPG和BMI预测GDM
的ROC曲线下面积分别为0.654、0.627 (P<0.05)。结论 孕前FPD及BMI对预测GDM的发生有一定的临床价值。

      【关键词】 孕前检查；妊娠期糖尿病；空腹血糖；体质量指数

      【中图分类号】 R714.256 【文献标识码】 A 【文章编号】 1003—6350（2016）19—3185—03


Predictive effect of fasting blood glucose and body mass index on pre-pregnancy women for gestational diabetes
mellitus.
LIU Xiao-dan, XU Jing. Department of Obstetrics, the Second People's Hospital of Liaocheng, Liaocheng 252600,
Shandong, CHINA

【Abstract】 Objective To investigate the predictive value of fasting blood glucose (FPG) and body mass index
(BMI) of pre-pregnancy women for gestational diabetes mellitus, and to provide the basis for early prevention of gesta-
tional diabetes mellitus (GDM). Methods A total of 385 pregnant women who underwent pre-pregnancy health exami-
nation and prenatal examination after pregnancy in our hospital from May 2013 to December 2014 were selected. All
women were performed gestational oral glucose tolerance test (OGTT) in the 24~28 weeks of gestational age. Logistic
regression analysis was used to analyze the risk factors associated with GDM. The predictive value of pre-pregnancy
FPG and BMI on GDM were analyzed by ROC curve. Results A total of 73 cases of GDM were found, with an inci-
dence rate of 18.96%. Pregnant women were divided into GDM group and control group according to whether they had
GDM. The ratio of age, pre-pregnancy FPG, BMI, systolic blood pressure and family history of diabetes in GDM group
were higher than those in control group, and the differences were statistically significant (P<0.05). Logistic regression
analysis showed that age, pre-pregnancy FPG, pre-pregnancy BMI and family history of diabetes were risk factors for
GDM in pregnant women. Predictive value analysis showed that the sensitivity and specificity were 67.12% and 63.46%
(respectively) when FPG was 4.6~4.8 mmol/L, andand the sensitivity and specificity were 58.90% and 59.62% when
BMI was 23.0~25.0 kg/m2. The area under the ROC curve of pre-pregnancy FPG and BMI were respectively 0.654,
0.627 (P<0.05). Conclusion Pre-pregnancy FPD and BMI have certain clinical value for predicting GDM.

      【Key words】 Pre-pregnancy examination; Gestational diabetes mellitus (GDM); Fasting blood glucose (FBG);
Body mass index (BMI)
·论 著·doi:10.3969/j.issn.1003-6350.2016.19.030