标题：血清PCT 和CRP 对癌症化疗后腹泻患者肠原性细菌感染的检测价值

      作者：张小兵 1，白利青 2
    （1.榆林市中医医院北方医院检验科，陕西 榆林 719000；
2.榆林市星元医院检验科，陕西 榆林 719000）

      卷次： 2016年27卷19期

      【摘要】 目的 探究血清降钙素原(PCT)和C反应蛋白(CRP)对癌症化疗后腹泻患者肠原性细菌感染的检测
价值。方法 将我院2012年1月至2014年6月就诊的42例化疗后腹泻患者作为观察组进行腹泻等级评估，其中1
级17例，2级13例，3级8例，4级4例；58例化疗后无腹泻患者作为对照组。采用化学免疫发光法检测PCT水平，免
疫散射比浊法检测CRP水平。比较各组患者血清PCT和CRP含量。结果 观察组腹泻1级到4级PCT、CRP含量
逐渐升高，对照组与观察组腹泻1级、2级比较，PCT、CRP水平差异均无统计学意义(P<0.05)，对照组、观察组腹泻1
级、2级与观察组3级、4级PCT、CRP水平差异均有统计学意义(P<0.05)。观察组PCT阳性率为88.09% (37/42)，明
显高于对照组的12.07% (7/58)，差异具有统计学意义(P<0.05)；观察组CRP阳性率为95.23% (40/42)，明显高于对照
组的51.72% (30/58)，差异具有统计学意义(P<0.05)。结论 癌症化疗后腹泻患者血清PCT和CRP对诊断腹泻肠原
性细菌感染具有一定的临床参考价值，为临床应用提供了一定的科学依据。

      【关键词】 癌症；腹泻；血清降钙素原；C反应蛋白；肠原性细菌感染

      【中图分类号】 R730.53 【文献标识码】 A 【文章编号】 1003—6350（2016）19—3129—03


Detection value of PCT and CRP in enterogenous bacterial infections among cancer diarrheal patients after
chemotherapy.
ZHANG Xiao-bing 1, BAI Li-qing 2. 1. Clinical Laboratory, the Northern Hospital of Traditional Chinese
medicine Hospital of Yulin City, Yulin 719000, Shaanxi, CHINA; 2. Clinical Laboratory, the Xingyuan Hospital of Yulin
City, Yulin 719000, Shaanxi, CHINA

【Abstract】 Objective To study the detection value of procalcitonin (PCT) and C-reactive protein (CRP) in en-
terogenous bacterial infections among cancer diarrheal patients after chemotherapy. Methods A total of 42 cases of can-
cer diarrheal patients, who admitted to our hospital from January 2012 to June 2014, were selected as the observation
group. After the treatment of chemotherapy, these patients were evaluated the diarrhea grade and divided into 17 cases of
grade 1, 13 cases of grade 2, 8 cases of grade 3 and 4 cases of grade 4. Fifty-eight cases of patients without diarrhea were
selected as the control group. The PCT and CRP levels were detected respectively by chemiluminescence immunoassay
(CLIA) and turbidimetric inhibition immunoassay (TINIA), and the difference of serum PCT and CRP between groups
were compared. Results The PCT and CRP levels of diarrhea grade 1 to grade 4 in the observation group gradually in-
creased. There was no significant difference between the two groups in diarrhea grade 1 and 2 (P>0.05). There was sig-
nificant difference between the grade 1, 2 and grade 3, 4 in the two groups (P<0.05). PCT and CRP positive rates in the
observation group were significantly higher than those in the control group 88.09% (37/42) vs 12.07% (7/58), 95.23%
(40/42) vs 51.72% (30/58), P<0.05. Conclusion Serum PCT and CRP can help estimate diarrhea enterogenous bacteri-
al infection in patients with cancer after chemotherapy, and provide a scientific basis for clinical application.

      【Key words】 Cancer; Diarrhea; Serum procalcitonin; C-reactive protein (CRP); Intestinal bacterial infection