标题：Rho/ROCK通路抑制剂在青光眼中的研究进展

      作者：何理烨，梁亮
    (三峡大学第一临床医学院眼科 三峡大学眼科与视觉科学研究所，湖北 宜昌 443000)

      卷次： 2016年27卷13期

      【摘要】 Rho/ROCK通路在细胞骨架的调节方面起到重要作用。Rho/ROCK抑制剂可以通过调节小梁网中肌
动蛋白细胞骨架、细胞外基质以及Schlemm's管内皮细胞功能，从而降低眼压。同时，抑制Rho/ROCK途径，可增加
视乳头血流量、维持视网膜神经节细胞生存、促进轴突再生，甚至发现在抗青光眼滤过术后能抗瘢痕化。考虑到其
眼压调节、抗瘢痕作用和视神经保护特性，Rho/ROCK信号通路是抗青光眼治疗的重要目标，在不久的将来它将用
于青光眼的推荐治疗方案。

      【关键词】 Rho/ROCK通路；肌动蛋白细胞骨架；青光眼；视神经保护

      【中图分类号】 R775.2 【文献标识码】 A 【文章编号】 1003—6350（2016）13—2161—04


Research progress of Rho/ROCK pathway inhibitors in glaucoma.
HE LI-ye, LIANG Liang. Department of
Ophthalmology, the First Clinical Medical College of China Three Gorges University; Institute of Vision and Ophthalmology,
China Three Gorges University, Yichang 443000, Hubei, CHINA
【Abstract】 The Rho/ROCK pathway plays an important role in the regulation of cytoskeleton. Rho /ROCK in-
hibitor reduces the intraocular pressure (IOP) through modulate of the actin cytoskeleton in trabecular meshwork and ad-
justs the function of extracellular material and Schlemm's vascular endothelial cells. At the same time, the inhibition of
Rho/ROCK can increase the flow of the optic nerve head, maintain the survival of retinal ganglion cells, promote the re-
generation of axons and even can be found the function of anti-scarring after glaucoma filtration surgery. Taking into ac-
count the effect of the regulation of intraocular pressure, anti scarring and the protection of the optic nerve, Rho/ROCK
signaling pathway is an important target for the treatment of glaucoma. It will be used for the treatment of glaucoma in
the near future.

      【Key words】 Rho/ROCK pathway; Actin cytoskeleton; Glaucoma; Optic nerve neuroprotection
·综 述·
6350.2016.13.033