标题：早期子宫内膜癌患者的复发和生存状况研究

      作者：张海云，边红侠，冯艳霞
    (榆林市中医院妇产科，陕西 榆林 719000)

      卷次： 2016年27卷13期

      【摘要】 目的 观察早期子宫内膜癌患者的复发和生存状况，探讨其影响因素。方法 回顾性分析2007年1
月至 2010年 12月期间我院妇产科收治的 78例早期子宫内膜癌患者的临床病理资料和术后生存状况。采用
Kaplan-Meier法计算年龄、病理分级、类型等各亚组3年无病生存率(DFS)，并用Log-rank检验进行比较。采用单因
素和多因素Cox比例风险回归模型进行预后分析。结果 78例患者术后均获得随访，随访时间为6~79个月，中位
随访时间为58个月。全部患者中复发13例(16.7%)，中位复发时间为46个月(6~76个月)，其中10例在术后5年内
复发。全部患者的3年DFS为91.5%。病理分期、分级、类型、肿瘤最大径、术前血清CA125水平是导致直肠癌患者
预后不良的独立危险因素，而淋巴结清扫是其保护因素(P<0.05)。结论 早期子宫内膜癌的整体预后较好，但对于
Ⅱ期、G3级、特殊类型、肿瘤最大径>2 cm、术前血清CA125水平>35 kU/L、未进行淋巴结清扫的患者应在术后5年
内密切随访，早期发现复发转移。

      【关键词】 子宫内膜癌；早期；复发；生存状况；预后

      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2016）13—2153—04


Study of recurrence and survival status of patients with early stage endometrial cancer.
ZHANG Hai-yun, BIAN
Hong-xia, FENG Yan-xia. Department of Gynaecology and Obstetrics, Yulin Hospital of Traditional Chinese Medicine,
Yulin 719000, Shaanxi, CHINA

【Abstract】 Objective To observe the recurrence and survival status of patients with early stage endometrial
cancer, and to investigate the influence factors. Methods Clinical data and postoperative survival status of 78 patients
with early stage endometrial cancer from January 2007 to December 2010 were retrospectively analyzed. Kaplan-Meier
method was used to calculate 3-year disease-free survival (DFS) of each sub-group of age, pathologic stage, type and so
on, and then Log-rank test was performed to compare them. Univariate and multivariate Cox proportional hazard re-
gression model were used for prognosis analysis. Results All the patients were followed up for 6~79 months, with
the median of 58 months. Among the 78 patients, 13 cases (16.7%) recurred, and the median recurrence time was 46
months (6~76 months), of which 10 cases recurred within 5 years after operation. All patients' 3-year DFS was
91.5%. Pathological staging, grading, type, the maximal tumor diameter, preoperative serum CA125 level were the
independent risk factors of poor prognosis in patients with rectal cancer, but lymph node dissection was the protec-
tive factor (P<0.05). Conclusion The overall prognosis of patients with early stage endometrial cancer is better. How-
ever, the patients with phase Ⅱ, grade G3, special type, the maximal tumor diameter>2 cm, preoperative serum CA125
level>35 kU/L and without lymph node dissection should be closely followed up within 5 years after operation, to early
detect recurrence and metastasis.

      【Key words】 Endometrial cancer; Early; Recurrence; Survival status; Prognosis
·论 著·
6350.2016.13.031