标题：VASH1在口腔鳞状细胞癌、口腔白斑及口腔扁平苔藓中的表达及意义

      作者：孙 鑫，魏秀峰，吕珊珊，刘 桐，安欢欢，李 娜，谷 楠
    (吉林大学口腔医院口腔黏膜病科，吉林 长春 130021）

      卷次： 2015年26卷23期

      【摘要】 目的 探讨血管生成抑制蛋白1 (VASH1)在口腔鳞状细胞癌(OSCC)、口腔白斑(OLK)和口腔扁平
苔藓(OLP)中的表达及意义。方法 免疫组织化学染色SP法检测60例OSCC、20例OLK、20例OLP及20例正常
口腔黏膜(NOM)中VASH1的表达情况，采用SPSS19.0软件对结果进行统计学分析。结果 (1) VASH1蛋白在
OSCC组织中的阳性表达率和染色强度随组织分化程度的降低而呈增高趋势(P<0.05)，并且在中、低分化的鳞状
细胞癌中的表达明显高于白斑，差异有统计学意义(P<0.05)；(2) VASH1在白斑中的表达明显高于正常组织和
扁平苔藓，且差异有统计学意义(P<0.05)；(3) VASH1在扁平苔藓与正常组织的表达情况差异无统计学意义
(P>0.05)；(4)口腔鳞癌组中VASH1在有淋巴转移组的表达明显高于无淋巴转移组，差异有统计学意义(P<0.05)。
结论 VASH1蛋白可能与口腔鳞状细胞癌的发生、发展及转移有关。

      【关键词】 血管生成抑制蛋白1；口腔鳞状细胞癌；口腔白斑

      【中图分类号】 R739.85 【文献标识码】 A 【文章编号】 1003—6350（2015）23—3560—03


Expression and significance of VASH1 protein in oral squamous cell carcinoma, oral leukoplakia and oral
lichen planus.
SUN Xin, WEI Xiu-feng, LV Shan-shan, LIU Tong, AN Huan-huan, LI Na, GU Nan. Department of Oral
Mucosal Disease Office, Hospital of Stomatology, Jilin University, Changchun 130021, Jilin, CHINA

【Abstract】 Objective To explore the expression of vasohibin1 (VASH1) in oral squamous cell carcinoma
(OSCC), oral leukoplakia (OLK), oral lichen planus (OLP). Methods Immunohistochemistry was used to detect the
expression of VASH1 in 60 cases of OSCC, 20 cases of OLK, 20 cases of OLP and 20 cases of normal oral tissue.
SPSS19.0 was used for statistical analysis. Results (1) The positive expression and staining intensity of VASH1 pro-
tein in the OSCC tissue showed an increasing trend with the decreasing of the tissue differentiation degree (P<0.05).
The expression of VASH1 in moderately and poorly differentiated OSCC was significantly higher than that in OLK
(P<0.05). (2) The expression of VASH1 in OLK was significantly higher in that in normal oral mucosa (NOM) and
OLP (P<0.05). (3) The expression of VASH1 in OLP and NOM showed no statistically significant difference (P>
0.05). (4) The expression of VASH1 in oral squamous cell carcinoma with lymph node metastsis group was significant-
ly higher than that without lymph node metastasis group (P<0.05). Conclusion VASH1 protein may be related to the
occurrence of OSCC, development and metastasis.

      【Key words】 Vasohibin1 (VASH1); Oral squamous cell carcinoma (OSCC); Oral leukoplakia (OLK)