标题：STAT3和p-STAT3与非霍奇金淋巴瘤预后关系的Meta分析

      作者：李春瑶 1，黄兰姗 1，陈 罡 1，冯振博 1，甘廷庆 2，杨丽桦 2
    (广西医科大学第一附属医院病理科 1、肿瘤内科 2，广西 南宁 530021)

      卷次： 2015年26卷22期

      【摘要】 目的 应用Meta分析的方法，阐明信号传导与转录激活因子3与磷酸化的信号传导与转录激活因
子 3在非霍奇金淋巴瘤中的表达及其与患者预后的关系。方法 计算机检索 PubMed、Cochrane图书馆、
Embase、ISI Web of Science、中国知网、万方数据、维普数据库，根据纳入和排除标准进行筛选，确定纳入文献后提
取数据，用 Stata 12.0进行Meta分析。结果 共纳入 6篇文献，累计病例 855例。随机效应模型合并风险比
(Hazard ratio，HR)为 1.03(95%CI: 0.43~2.44，P=0.954)，差异无统计学意义。以生发中心 B细胞样 (Germinal
center B-cell-like，GCB)及非生发中心 B细胞样(Non-GCB)亚组进行分析，固定效应模型合并 HR值为 1.82
(95%CI：1.30~2.56，P=0.000)，差异有统计学意义。结论 STAT3或p-STAT3的高表达与NHL的预后无明显相关
关系，但可能与GCB和non-GCB亚型的不良预后有关。

      【关键词】 STAT3；p-STAT3；非霍奇金淋巴瘤；预后；Meta分析

      【中图分类号】 R730.263 【文献标识码】 A 【文章编号】 1003—6350（2015）22—3382—05


Relationship between STAT3, p-STAT3 and prognosis of non-Hodgkin's lymphoma: a meta-analysis.
LI Chun-yao 1, HUANG Lan-shan 1, CHEN Gang 1, FENG Zheng-bo 1, GAN Yan-qing 2, YANG Li-hua 2.
Department of
Pathology 1, Department of Oncology 2, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021,
Guangxi, CHINA

【Abstract】 Objective To quantitatively assess the role of signal transducer and activator of transcription 3
(STAT3) and phospho-STAT3 (p-STAT3) expression in non-Hodgkin's lymphoma (NHL) and analyze their correlation
with the prognosis of patients with lymphoma. Methods PubMed, Cochrance Library, Embase, ISI Web of Science,
CNKI, Wanfang and VIP databases were searched. Literatures were screened according to the inclusion and exclusion
criteria, and survival data were extracted after the literatures were confirmed. Meta-analysis was conducted using Stata
12.0. Results A total of 6 references were included with 855 patients. The combined hazard ratio (HR) was 1.03
(95%CI: 0.43~2.44, P=0.954) by random-effect model without statistical significance. Pooled HR of germinal cen-
ter B-cell-like (GCB) and non-germinal center B-cell-like (non-GCB) subgroups was 1.82(95%CI: 1.30~2.56, P=
0.000) by fixed-effect model, showing statistical significance. Conclusion High STAT3 or p-STAT3 expression
has no significant correlation with prognosis of NHL, but they may indicate poor prognosis in GCB and non-GCB
subgroups.

      【Key words】 STAT3; p-STAT3; Non-Hodgkin's lymphoma; Prognosis; Meta-analysis