标题：光线与温度对罗库溴铵在全麻患者中效价的影响

      作者：胡皓琳，夏中元，赵 博，侯家保，吴 洋
    （武汉大学人民医院麻醉科，湖北 武汉 430060）

      卷次： 2015年26卷22期

      【摘要】 目的 观察光线与温度对罗库溴铵在全麻患者中的效价。方法 选取拟在我院行全麻手术患者
60例，随机分为6组，低温光照2周组(DG2组)、常温避光2周组(CB2组)、低温避光2周组(DB2组)、低温光照4周
组(DG4组)、常温避光4周组(CB4组)、低温避光4周组(DB4组)。麻醉诱导待患者意识消失后行肌松监测，初始
数值记录后启动肌松监测仪泵注罗库溴铵，记录6组患者的诱导时间、增药时间及增药量。结果 在贮藏时间相
同时，与DB组比较，DG组和CB组诱导时间、增药量增加，增药时间缩短，差异具有统计学意义(P<0.05)；在贮藏
条件相同时，4周组较2周组诱导时间、增药量增加，增药时间缩短，差异具有统计学意义(P<0.05)。结论 光线
与温度均会降低罗库溴铵的效价，随着时间的延长罗库溴铵的效价也会缓慢降低。

      【关键词】 罗库溴铵；光线；温度；全麻

      【中图分类号】 R614.2 【文献标识码】 A 【文章编号】 1003—6350（2015）22—3369—02


Effect of illumination and temperature on rocuronium in general anesthesia.
HU Hao-lin, XIA Zhong-yuan,
ZHAO Bo, HOU Jia-bao, WU Yang. Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan
430060, Hubei, CHINA

【Abstract】 Objective To explore the effect of illumination and temperature on rocuronium in general anesthesia.
Methods Sixty patients scheduled for general anesthesia were randomly divided into 6 groups (n=10): group DG2 (treat-
ed with low temperature and illumination for 2 weeks, group CB2 (normal temperature and non-illumination for 2 weeks),
group DB2 (low temperature and non-illumination for 2 weeks), group DG4 (low temperature and illumination for 4
weeks), group CB4 (normal temperature and non-illumination for 4 weeks), group DB4 (low temperature and non-illu-
mination for 4 weeks). After the patients lose consciousness, neuromuscular monitoring was performed, with rocuroni-
um administrated. The induction time, adding time and adding dose were recorded. Results Under the same storage
time, group DG and group CB needed longer induction time, more adding dose, shorter adding time than group DB
(P<0.05). Under the same storage conditions, 4 weeks group had longer induction time, more adding dose, and shorter
adding time than 2 weeks group (P<0.05). Conclusion Illumination and temperature can decrease the effect of ro-
curonium, and the effect of rocuronium is slowly reduced with time going on.

      【Key words】 Rocuronium; Illumination; Temperature; General anesthesia
·临床经验·