标题：2型糖尿病合并冠心病患者血清中APN、IL-6及hs-CRP的水平及其相关性研究

      作者：关清华 1，旷劲松 1，张秀斌 1，程 岚 1，陈芬琴 2
    (1.沈阳市第四人民医院内分泌科，辽宁 沈阳 110031；
2.中国医科大学附属第一医院干诊科，辽宁 沈阳 110001)

      卷次： 2015年26卷22期

      【摘要】 目的 观察脂联素(APN)、白细胞介素-6 (IL-6)及超敏C反应蛋白(hs-CRP)在2型糖尿病(T2DM)合
并冠心病(CHD)患者中的水平，并探讨其相关性。方法 选择临床确诊的T2DM患者 80例，分为T2DM不伴
CHD组 40例(B组)和 T2DM合并 CHD组(C组)40例，并与 40例健康体检者(A组)对照，采用酶联免疫吸附
(ELISA)法测定三组受试者的血清APN、IL-6及hs-CRP的水平，常规检测糖化血红蛋白(GHbA1c)，并应用Pearson
相关性分析统计其相关性。结果 C组患者血清hs-CRP、IL-6水平均明显高于B组和A组，且差异均有统计学
意义(P<0.05)，而血清APN水平则明显低于B组和A组，且差异有统计学意义(P<0.05)；相关分析显示，C组患者
的 hs-CRP与 IL-6水平呈显著正相关(r=0.725，P<0.05)，GHbA1c与 hs-CRP及 IL-6水平呈显著正相关(r=0.873、
0.912，P均<0.01)，而APN与hs-CRP及 IL-6水平呈显著负相关(r=-0.816、-0.79，P均<0.01)。结论 APN作为抗
动脉粥样硬化(AS)病变的保护因子而 IL-6、hs-CRP作为致AS病变的炎症因子，它们共同参与了T2DM合并
CHD患者冠脉粥样硬化的发生发展，早期干预这些炎症因子的水平可有效延缓T2DM患者CHD的发生发展。

      【关键词】 2型糖尿病；冠心病；脂联素；白细胞介素-6；超敏C反应蛋白

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2015）22—3298—04


Serum levels of adiponectin, interleukin-6, high sensitivity C-reactive protein and their correlation in type 2
diabetic patients with coronary heart disease.
GUAN Qing-hua 1, KUANG Jin-song 1, ZHANG Xiu-bin 1, CHENG Lan 1,
CHEN Fen-qin 2. 1. Department of Endocrinology, the Fourth People's Hospital of Shenyang, Shenyang 110031,
Lianning, CHINA; 2. VIP Clinic, the First Hospital of China Medical University, Shenyang 110001, Lianning, CHINA

【Abstract】 Objective To investigate the serum levels of adiponectin (APN), interleukin-6 (IL-6), high sen-
sitivity C-reactive protein (hs-CRP) and their correlation in patients of type 2 diabetes mellitus (T2DM) with coronary
heart disease (CHD). Methods Eighty T2DM patients were divided into two groups: 40 patients with CHD (group
C) and 40 patients without CHD (group B). Forty healthy subjects were enrolled as the control people (group A). The
levels of APN, IL-6 and hs-CRP in these three groups were measured by ELISA assay, and the level of glycosylated
hemoglobin A1c (GHbA1c) was routinely detected. Pearson correlation analysis was used to analyze the correlation be-
tween the three indexes. Results IL-6 and hs-CRP levels in group C were significantly higher than those in group B
and group A (P<0.05), while APN level in group C was significantly lower compared with group B and group A (P<
0.05). According to correlation analysis, serum hs-CRP level was positively correlated with IL-6 (r=0.725, P<0.05),
with serum GHbA1c positively correlated with hs-CRP and IL-6 (r=0.873, 0.912, P<0.01), while serum APN level was
negatively correlated with hs-CRP and IL-6 in group C (r=-0.816, -0.79, P<0.01). Conclusion APN is an antiath-
erogenic factor for atheromatosis, while IL-6 and hs-CRP are inflammatory factors resulting in atheromatosis. These
three factors all participate in the pathogenesis and progression of atherosclerosis in T2DM patients with CHD. Early
intervention for these inflammatory factors level can effectively delay the development of CHD in T2DM patients.

      【Key words】 Type 2 diabetes mellitus (T2DM); Coronary heart disease; Adiponectin; Interleukin-6; High sen-
sitivity C-reactive protein
基金项目：沈阳市科技局课题（编号：F12-193-9-24）