标题：小胶质细胞/脑巨噬细胞与胶质瘤研究进展

      作者：张思磊，王雄伟
    (三峡大学神经病研究所三峡大学第一临床医学院神经外科，湖北 宜昌 443003)

      卷次： 2015年26卷20期

      【摘要】 胶质瘤是脑肿瘤中最常见的类型，其强大的侵袭力是一个非常棘手的临床问题，恶性肿瘤侵袭转
移机制是肿瘤学研究的热点。小胶质细胞/脑巨噬细胞在胶质瘤的发展及侵袭过程中具有两方面作用，可以在胶
质瘤微生态环境中通过胶质瘤分泌释放细胞因子调控促进胶质瘤的增生扩张，也能在人为作用影响下发挥肿瘤
免疫作用。小胶质细胞/脑巨噬细胞透过血脑屏障改变肿瘤微生态环境使其表现为抑制胶质瘤侵袭扩张，将可能
为胶质瘤的研究及治疗提供新思路和方法。

      【关键词】 胶质瘤；侵袭；小胶质细胞/脑巨噬细胞

      【中图分类号】 R730.364 【文献标识码】 A 【文章编号】 1003—6350（2015）20—3038—03


Research advance in microglia/brain macrophage and glioma.
ZHANG Si-lei, WANG Xiong-wei. Department of
Neurosurgery, the First Clinical Medical College of China Three Gorges University, Institute of Neuroscience of China
Three Gorges University, Yichang 443003, Hubei, CHINA
【Abstract】 Glioma represents the most frequent type of human brain tumor, and its strong invasiveness is a sig-
nificant clinical problem. Invasion and metastasis mechanism of malignant tumor is still a hot spot of oncological re-
search. Microglia/brain macrophages have double effects on the expansion and invasion of glioma. On one hand, they
can promote the expansion, invasion of glioma by release factor under the microenvironment of tumor. On the other
hand, they can kill tumor cell in tumor immunity by the influence of human. Microglia/brain macrophages go cross the
blood-brain barrier to change the glioma microenvironment and inhibit the expansion, invasion of glioma. The study of
microglia/brain macrophages would provide new ideas and methods for research and treatment of gliomas.

      【Key words】 Glioma; Invasion; Microglia/brain macrophages