标题：滑膜MMP-3对骨性关节炎患者病情的评估价值

      作者：胡振勇，辛海松
    (黄骅市人民医院骨一科，河北 黄骅 061100)

      卷次： 2015年26卷20期

      【摘要】 目的 探讨滑膜基质金属蛋白酶 3 (MMP-3)对骨性关节炎患者病情的评估价值。方法 选取
2011年1月至2015年4月收治的骨性关节炎患者106例为骨性关节炎组，另选取滑膜皱襞综合征、单纯膝关节半
月板损伤或者截肢的患者30例为对照组。Envision二步法检测滑膜MMP-3表达水平。结果 骨性关节炎组与
对照组MMP-3表达阳性细胞率分别为92.45%和20.00%，两组比较差异具有显著统计学意义(P<0.01)；随着骨性
关节炎患者病变程度升高，MMP-3表达水平逐渐升高，骨性关节炎患者病变程度与MMP-3表达水平呈正相关
性(r=0.765，P=0.021)。结论 MMP-3在骨性关节炎患者滑膜中呈高表达水平，其表达水平与病变程度相关，可
作为判断骨性关节炎病情的重要指标。

      【关键词】 骨性关节炎；基质金属蛋白酶(MMP-3)；表达

      【中图分类号】 R684.3 【文献标识码】 A 【文章编号】 1003—6350（2015）20—2995—03


Value of MMP-3 expression level in evaluating the grade of osteoarthritis.
HU Zhen-yong, XIN Hai-song. The
First Department of Orthopedics, the People's Hospital of Huanghua City, Huanghua 061100, Hebei, CHINA

【Abstract】 Objective To investigate the value of matrix metalloproteinases 3 (MMP-3) expression level in
the evaluation of the grade of osteoarthritis. Methods One hundred and six patients with osteoarthritis in our hospi-
tal from Jan. 2011 to Apr. 2015 were selected as osteoarthritis group, and another 30 patients with synovial plica syn-
drome, knee meniscus injury and amputation were enrolled as control group. Envision two step method was used to de-
termine the MMP-3 expression level at synovium. Results The positive MMP-3 expression rate of osteoarthritis
group and control group were 92.45% and 20.00%, respectively, with significant difference between the two groups
(P<0.01). With the increasing of grade of osteoarthritis, MMP-3 expression level significantly increased. Grade of os-
teoarthritis was positively correlated with MMP-3 expression level (r=0.765, P=0.021). Conclusion MMP-3 ex-
pressed at high level at synovium in patients with osteoarthritis, and its expression level is positively correlated with
grade of osteoarthritis.

      【Key words】 Osteoarthritis; Matrix metalloproteinases 3 (MMP-3); Expression
·论 著·doi:10.3969/j.issn.1003-6350.2015.20.1090