标题：星形细胞上调基因-1在膀胱癌中的表达及意义

      作者：李生华 1，钟腾飞 2，张 鑫 2，熊天华 2，刘 柳 2，蒋一强 2，陈 罡 2
    (广西医科大学第一附属医院泌尿外科 1、病理科 2，广西 南宁 530021)

      卷次： 2015年26卷20期

      【摘要】 目的 探讨星形细胞上调基因-1 (AEG-1)在膀胱癌组织中的表达及其临床意义。方法 采用免
疫组织化学法检测224例膀胱癌组织及56例正常膀胱组织中AEG-1表达的差异及其与相关临床病理参数间的
关系。结果 AEG-1在膀胱癌组织中的表达显著高于正常膀胱组织(P<0.01)；男性膀胱癌患者AEG-1的表达明
显高于女性膀胱癌患者(P<0.05)；膀胱癌高级别组中的表达显著高于低级别组(P<0.01)；膀胱癌Ⅲ、Ⅳ期者显著高
于Ⅰ、Ⅱ期者 (P<0.01)；伴有淋巴结转移者AEG-1的表达显著高于无淋巴结转移者(P<0.01)；肿瘤直径≥3 cm组
AEG-1的表达显著高于肿瘤直径<3 cm组(P<0.01)。膀胱癌复发组AEG-1的表达显著高于无复发组(P<0.01)。
结论 AEG-1的高表达与膀胱癌的发生与演变密切相关。

      【关键词】 星形细胞上调基因-1；膀胱癌；免疫组化

      【中图分类号】 R737.14 【文献标识码】 A 【文章编号】 1003—6350（2015）20—2973—03


Expression and clinical significance of AEG-1 in bladder cancer tissues.
LI Sheng-hua 1, ZHONG Teng-fei 2,
ZHANG Xin 2, XIONG Tian-hua 2, LIU Liu 2, JIANG Yi-qiang 2, CHEN Gang 2. Department of Urinary Surgery 1,
Department of Pathology 2, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, CHINA

【Abstract】 Objective To investigate the expression and clinical significance of AEG-1 in bladder cancer tis-
sues. Methods Immunohistochemistry (IHC) was used to detect the expression of AEG-1 in 224 cases of bladder
cancer tissues and 56 cases of normal bladder tissues. The relationships between AEG-1 expression and clinical patho-
logical parameters were also analyzed. Results The expression of AEG-1 was significantly higher in bladder cancer
tissues than in normal bladder tissues (P<0.01), in male patients than female patients (P<0.05), in higher levels of blad-
der cancer than lower levels of bladder cancer (P<0.01), in bladder cancer tissues of stageⅢ andⅣ than bladder can-
cer tissues of stageⅠ andⅡ (P<0.01), in patients with lymphatic metastasis than those without lymphatic metastasis
(P<0.001), in patients with tumor diameter ≥3 cm than those with tumor diameter <3 cm (P<0.01), as well as in pa-
tients with recurrence than those without recurrence (P<0.001). Conclusion Overexpression of AEG-1 is closely cor-
related with tumorigenesis and development of bladder cancer.