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      标题:注射用灯盏花素联合华法林治疗永久性心房颤动随机平行对照研究
      作者:马莉 1,符业阳 2,刘月玲 2
    (广州医科大学附属第三医院心血管内科 1、药学部 2,广东 广州 510150)
      卷次: 2016年27卷13期
      【摘要】 目的 研究注射用灯盏花素对华法林治疗永久性心房颤动时抗凝效果是否存在影响,为临床合理使
用华法林提供参考。方法 收集我院2013年6月至2014年6月永久性心房颤动且适合华法林抗凝治疗的61例患
者,服用华法林抗凝且稳定达标后,按照随机数字法分为观察组31例和对照组30例,对照组单用华法林,观察组在
华法林的基础上联合注射用灯盏花素治疗,每周分别检测两组患者的凝血酶原时间(PT)、凝血酶原时间国际标准
化比值(INR),并记录两组患者的出血情况。结果 两组患者治疗后出血发生率、停药率、停药次数、停药天数和 INR
超出目标范围的比例比较差异均无统计学意义(P>0.05);观察组患者治疗后PT和 INR分别为(26.6±4.1) s和(2.5±0.4),
对照组分别为(21.6±4.3) s和(2.1±0.5),观察组明显高于对照组,差异均有统计学意义(P<0.05);观察组使用华法林剂
量为(2.0±2.0) mg,对照组为(2.6±2.2) mg,观察组显著低于对照组,差异有统计学意义(P<0.05)。结论 注射用灯盏
花素能延长永久性心房颤动患者的PT,升高 INR,临床联合使用时应根据具体情况适当调整华法林的剂量。

      【关键词】 注射用灯盏花素;华法林;心房颤动;抗凝治疗;凝血酶原时间

      【中图分类号】 R541.7+5 【文献标识码】 A 【文章编号】 1003—6350(2016)13—2093—03

Effect of breviscapine injection combined with warfarin on patients with permanent atrial fibrillation: A
randomized, parallel controlled clinical trial. MA Li 1, FU Ye-yang 2, LIU Yue-ling 2. Department of Internal
Medicine-Cardiovascular 1, Department of Pharmaceutical 2, the Third Affiliated Hospital of Guangzhou Medical University,
Guangzhou 510150, Guangdong, CHINA

      【Abstract】 Objective To study the anticoagulant effect of breviscapine injection combined with warfarin on
patients with permanent atrial fibrillation, and provide reference for the clinical use of warfarin. Methods A total of 61
cases of patients with permanent atrial fibrillation, who admitted to our hospital from June 2013 to June 2014, were suit-
ed for anticoagulant treatment with warfarin. After warfarin was used and meet stability standards, these patients were di-
vided into the treatment group (n=31) and the control group (n=30) according to the random number method. The control
group was treated with warfarin only, and breviscapine injection was added to the treatment group on the basis of warfa-
rin. The prothrombin time (PT), international normalized ratio (INR), and incidence of bleeding were detected and re-
corded for every week. Results There was no significant difference between the two groups after treatment in the inci-
dence of bleeding, the rate of drug withdrawal, the number of drug withdrawal, the number of drug withdrawal days and
the proportion of INR beyond the target range (P>0.05). The PT of treatment group [(26.6±4.1) s] was significantly high-
·论 著·
6350.2016.13.010


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