标题：青少年肥胖和母亲孕前超重对青少年支气管哮喘发病的影响

      作者：孔令玉 1，柴若南 1，刘 蕾 1，韩雅玲 2，马德宾 1
    (沈阳军区总医院呼吸内科 1、心内科 2，辽宁 沈阳 110016)

      卷次： 2015年26卷19期

      【摘要】 目的 明确青少年肥胖及其母亲孕前超重对青少年支气管哮喘发生的影响，并随访研究减轻体重
可否协助哮喘的治疗和控制。方法 采用同期对照实验，纳入同一时期就诊的哮喘青少年507例及非哮喘青少
年511例，研究其母亲及自身体质超重或肥胖的情况。将体质超重或肥胖的哮喘患儿纳入体重控制研究，在正规
治疗哮喘的同时，要求其父母协助患儿正规减重，分析体重减轻对患儿哮喘控制的影响。结果 哮喘青少年组
母亲孕前超重比例(115/507)明显高于非哮喘青少年组(90/511)，差异有统计学意义(P<0.05)；母亲孕前肥胖是青
少年发生哮喘的危险因素(OR1.37，95%CI 1.01~1.87，P=0.026)。同样，哮喘青少年组肥胖比例(155/507)也明显高
于非哮喘青少年(102/511)，差异有统计学意义(P<0.05)；青少年超重或肥胖也可能导致其哮喘发生(OR 1.77，
95%CI 1.32~2.35，P<0.01)。当青少年合理控制体重之后，其哮喘缓解情况明显优于体重对照组，差异有统计学
意义(P=0.025)。结论 母亲孕前超重及青少年肥胖均是支气管哮喘发生的危险因素，治疗哮喘的同时减轻体重
可有效提高哮喘控制率。

      【关键词】 哮喘；肥胖；孕前超重；青少年

      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350（2015）19—2827—04


Influence of adolescent obesity and maternal pre-pregnancy overweight on the occurrence of tracheal asthma.
KONG Ling-yu 1, CHAI Ruo-nan 1, LIU Lei 1, HAN Ya-ling 2, MA De-bin 1.
Department of Respiratory 1, Institute of
Cardiology 2, General Hospital of Shenyang Military Area Command, Shenyang 110016, Liaoning, CHINA

【Abstract】 Objective To determine the influence of adolescent obesity and maternal pre-pregnancy over-
weight on the occurrence of tracheal asthma among school-age children, and study whether weight loss could assist
the treatment and control of asthma. Methods In a concurrent control experiment, 507 cases of asthma adolescent pa-
tients (asthma group) and 511 cases of non-asthma adolescent patients (non-asthma group) were included during the
same period, with the overweight or obesity of themselves and their mothers studied. And then, asthma patients with
overweight or obesity were included into the research of weight-control: parents were asked to help patients to lose
weight healthily on the basis of regular treatment of asthma. The effect of weight loss on asthma control of children