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      标题:阿片肽与心肌缺血-再灌注损伤保护研究进展
      作者:田 超 1,韦 星 2,朱才义 1
    (1.中南大学湘雅医学院附属海口医院超声医学科,海南 海口 570208;
2.南华大学病理生理学教研室,湖南 衡阳 421000)
      卷次: 2015年26卷18期
      【摘要】 阿片肽及其受体广泛分布于心肌组织中,大量的研究显示阿片肽对心肌缺血-再灌注损伤具有显
著保护作用。其保护作用主要通过药理性预适应及后适应实现。本文就阿片肽发挥心肌预适应/后适应保护作
用的机制展开综述及展望。

      【关键词】 阿片肽;心肌缺血-再灌注;心肌保护

      【中图分类号】 R542.2 【文献标识码】 A 【文章编号】 1003—6350(2015)18—2728—03


Progress on opioid and cardioprotection in myocardial ischemia-reperfusion injury.

TIAN Chao 1, WEI Xin 2,
ZHU Cai-yi 1. 1. Department of Ultrasound, Haikou Hospital Affiliated to Xiangya Medical College of Central South
University, Haikou 570208, Hainan, CHINA; 2. Department of Pathophysiology, University of South China, Hengyang
421000, Hunan, CHINA
【Abstract】 Opioid receptors are widely distributed in the myocardial tissue. A large number of studies have
shown that opioid signaling system plays a protective role in myocardial ischemia-reperfusion injury. The cardiopro-
tective effect can be made by pharmacological ischemic preconditioning and postconditioning. This review focuses on
the latest advances of cardioprotective effect of the opioid system.

      【Key words】 Opioid; Ischemia-reperfusion; Cardioprotective effect

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