标题：乌司他丁联合机械通气治疗儿童ARDS疗效观察

      作者：吉训琦，冯小伟，陈玉雯
    (海南省人民医院儿科，海南 海口 570311)

      卷次： 2015年26卷18期

      【摘要】 目的 观察乌司他丁联合机械通气治疗儿童急性呼吸窘迫综合征(ARDS)的临床疗效。方法 回顾
性分析 2011年 1月至 2014年 6月本院儿科重症监护病房(PICU)收治的 56例ARDS患儿的临床资料，在机械
通气基础上，按是否使用乌司他丁分对照组(n=30)和治疗组(n=26)，比较两组患儿治疗后的肺功能改善情
况。结果 两组患儿机械通气前的PaO2/FiO2值[(129.7±16.7) vs (128.5±18.8)]和PaO2值[(46.7±6.8) vs (47.7±6.7)]
比较差异均无统计学意义(P>0.05)；两组患儿机械通气后24 h、48 h及72 h的PaO2/FiO2值、FiO2值与治疗前比较
均升高,差异均有统计学意义(P<0.05)；治疗组患儿机械通气后 24 h、48 h及 72 h的 PaO2/FiO2值、FiO2值与对照
组比较明显升高，差异均有统计学意义(P<0.05)；治疗组热程、机械通气时间均较对照组缩短，差异均有统计学意
义(P<0.05)。结论 乌司他丁联合机械通气治疗小儿ARDS临床疗效显著。

      【关键词】 乌司他丁；急性呼吸窘迫综合征；儿童；疗效

      【中图分类号】 R725.6 【文献标识码】 A 【文章编号】 1003—6350（2015）18—2704—03


Clinical effect of ulinastatin combining mechanical ventilation in the treatment of acute respiratory distress
syndrome in children.
JI Xun-qi, FENG Xiao-wei, CHEN Yu-wen. Department of Pediatrics, Peoples Hospital of
Hainan Provincial, Haikou 570311, Hainan,CHINA

【Abstract】 Objective To observe the curative effect of ulinastatin combining mechanical ventilation for
treating acute respiratory distress syndrome (ARDS) in children. Methods The clinical data of 56 children with AR-
DS in Pediatric Intensive Care Unit (PICU) from January 2011 to June 2014 were retrospectively analyzed. The patients
were divided into study group (n=26) and control group (n=30) according to whether they were treated by ulinastatin or
not. Then clinical features and lung function after treatment were compared between the two groups. Results Before
mechanical ventilation, the PaO2/FiO2 value [(129.7±16.7) vs (128.5±18.8)] and FiO2 value [(46.7±6.8) vs (47.7±6.7)]
of two groups had no statistically significant difference (P>0.05). 24 h, 48 h and 72 h after mechanical ventilation, the
PaO2/FiO2 value and FiO2 value of both groups were significantly increased, compared with those before treatment (P<
0.05), and the two values of the study group were significantly higher those in the control group (P<0.05). The fever
period and mechanical ventilation course of the study group were shortened than those in the control group, and the
differences were statistically significant (P<0.05). Conclusion Ulinastatin combining mechanical ventilation has sig-
nificant clinical effect for treating ARDS children.

      【Key words】 Ulinastatin; Acute respiratory distress syndrome (ARDS); Children; Clinical effect