标题：伴有牙周炎的 IgA肾病患者牙周治疗前后血清TNF-α与 IL-8变化分析

      作者：许志鹏 1，宋 勇 2，孙 燕 3
    （陕西省人民医院口腔科 1、肝胆外科 2、肾病科 3，陕西 西安 710068）

      卷次： 2015年26卷18期

      【摘要】 目的 观察伴有慢性牙周炎的 IgA肾病患者牙周治疗前后血清肿瘤坏死因子-α (TNF-α)和白细胞
介素-8 (IL-8)变化。方法 选取伴有慢性牙周炎的 IgA肾病患者50例(治疗组)和健康者30例(对照组)。对照组
不予特殊处理，治疗组采用超声洁牙和VECTOR牙周治疗仪进行牙周治疗，对照组于初诊时，治疗组于治疗前及
治疗后4周，分别检测两组受试者的牙周指数和血清TNF-α与 IL-8的浓度。血清中TNF-α与 IL-8的浓度采用酶
联免疫吸附法测定。结果 治疗组患者经过牙周治疗后，牙周状况明显好转，血清TNF-α与 IL-8浓度与治疗前
比较均明显降低，差异均有统计学意义(P<0.05)，但是牙周指数、TNF-α和 IL-8浓度仍高于对照组，差异均有统计
学意义(P<0.05)。结论 牙周治疗不仅可以有效改善牙周组织的病变，利于牙周炎的恢复，而且可降低血清中细
胞因子TNF-α、IL-8的水平，有助于对 IgA肾病患者肾病的治疗。

      【关键词】 牙周炎；肾病；清肿瘤坏死因子-α；白细胞介素-8

      【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350（2015）18—2681—03


Changes in levels of serum TNF-α and IL-8 before and after periodontal therapy for patients of IgA
nephropathy with periodontitis.
XU Zhi-peng 1, SONG Yong 2, SUN Yan 3. Department of Stomatology 1, Department of
Hepatobiliary Surgery 2, Department of Nephrology 3, People's Hospital of Shaanxi Province, Xi'an 710068, Shaanxi,
CHINA

【Abstract】 Objective To examine the levels of serum tumor necrosis factor-α (TNF-α) and interleukin-8
(IL-8) for IgA nephropathy patients with periodontitis before and after periodontal therapy. Methods Fifty pa-
tients of IgA nephropathy with chronic periodontitis (study group) and 30 healthy individuals (control group) were in-
cluded in this study. The study group was treated by ultrasonic and VECTOR periodontal therapy apparatus, whereas
the control group received no special treatment. We measured the periodontal indexes, and serum TNF-α and IL-8 lev-
els by enzyme-linked immunosorbent assay (ELISA) at the visit of doctor in the control group as well as before treat-
ment and 4 weeks after treatment in the study group. Results After periodontal therapy, the periodontal status was
significantly improved, with the levels of periodontal indexes and serum TNF-α and IL-8 significantly decreased.
Compared with the control group, the periodontal indexes and the serum TNF-α and IL-8 were still significantly higher.
Conclusion Periodontal treatment can not only effectively improve the periodontal lesions and promote the recovery
of periodontitis, but also reduce the levels of serum TNF-α and IL-8 and benefit the treatment for IgA nephropathy.

      【Key words】 Periodontitis; Nephropath; Tumor necrosis factor-α (TNF-α); Interleukin-8 (IL-8)
·论 著·doi:10.3969/j.issn.1003-6350.2015.18.0975