标题：COX-2蛋白和VEGF-C蛋白在胃癌和非胃癌黏膜病变组织中的表达及临床意义

      作者：陈美霓 1，郭 浩 2，郭 巍 2，郝 琴 1，赵菊梅 1，魏晓丽 1，王爱红 1，庞秋霞 1
    (1.延安大学医学院实验中心，陕西 延安 716000；
2.延安大学医学院附属医院，陕西 延安 716000)

      卷次： 2015年26卷18期

      【摘要】 目的 研究环氧合酶-2 (COX-2)蛋白和血管内皮生长因子C (VEGF-C)蛋白在胃癌组织和非胃癌
黏膜病变组织中的表达及其临床意义。方法 应用免疫组织化学S-P法检测45例胃癌标本、107例非胃癌黏膜
病变组织及23例胃癌手术癌旁正常黏膜组织中COX-2蛋白、VEGF-C蛋白的阳性表达情况，应用SPSS16.0统计
软件进行数据整理分析。结果 ①胃癌组织中COX-2蛋白、VEGF-C蛋白表达程度明显高于非胃癌黏膜病变组
织及正常胃黏膜组织(P<0.05)；②胃癌组织中COX-2蛋白、VEGF-C蛋白表达程度与淋巴结转移和临床分期相关
(P<0.05)；③COX-2蛋白与 VEGF-C蛋白在胃癌组织中的表达呈正相关 (P<0.05)。结论 COX-2蛋白与
VEGF-C蛋白在胃癌前病变发展为胃癌的过程中起着重要作用。COX-2蛋白、VEGF-C蛋白在胃癌的进展及淋
巴的转移过程中密不可分，COX-2蛋白、VEGF-C蛋白之间共同作用促进胃癌的淋巴转移。

      【关键词】 环氧合酶-2；血管内皮生长因子C；胃癌；免疫组化

      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350（2015）18—2671—04


Expression and significance of COX-2 and VEGF-C protein in gastric carcinoma and non-gastric mucosal
lesion tissues.
CHEN Mei-ni 1, GUO Hao 2, GUO Wei 2, HAO Qin 1, ZHAO Ju-mei 1, WEI Xiao-li 1, WANG Ai-hong 1,
PANG Qiu-xia1. 1. Medical Experiment Center, Medical College of Yan'an University, Yan'an 716000, Shaanxi, CHINA;
2. The Affiliated Hospital of Medical College of Yan'an University, Yan'an 716000, Shaanxi, CHINA

【Abstract】 Objective To study the expression and significance of cyclooxygenase-2 (COX-2) and vascular
endothelial growth factor-C (VEGF-C) in gastric carcinoma and non-gastric mucosal lesion tissues. Methods Immu-
nohistochemical SP was performed to detect the expression of COX-2 protein and VEGF-C protein in 45 cases of gas-
tric carcinoma, 107 cases of non-gastric mucosal lesion tissues, and 23 cases of peficancerous normal mucosal tissues.
Statistical analysis was performed using SPSS16.0 software. Results ① The expression of VEGF-C and COX-2 in
gastric carcinoma tissues was significantly higher than that in non-gastric mucosal lesion tissues and peficancerous
normal mucosal tissues (P<0.05);② The expression of COX-2 and VEGF-C in gastric carcinoma tissues was correlat-
ed with lymphatic metastasis and clinical staging (P<0.05);③ The expression of COX-2 was found to be positive cor-
related with the VEGF-C in gastric carcinoma tissues (P<0.05). Conclusion The COX-2 and VEGF-C protein play
an important role in the development from precancerous lesions to cancer. The COX-2 protein and VEGF-C protein
are closely related to the gastric cancer progression and lymphatic metastasis. The interaction between the COX-2 pro-
tein and VEGF-C protein promote lymphatic metastasis of gastric cancer.