标题：不同自主神经干预对家犬交感神经系统的影响

      作者：周丽平，余锂镭，王 卓，黄 兵，王松云，廖 凯，萨仁高娃，江 洪
    （武汉大学人民医院心内科，湖北 武汉 430060）

      卷次： 2015年26卷18期

      【摘要】 目的 研究不同自主神经干预方法对家犬交感神经系统的影响。方法 40只成年家犬随机分为
肾交感神经消融(RSD)组(n=8)、低强度耳缘迷走神经刺激(LL-TS)组(n=8)、低强度颈动脉窦压力感受器刺激
(LL-CBS)组(n=8)、低强度脊髓神经刺激(LL-SCS)组(n=8)和对照组(n=8)。分别在基础状态、干预1 h、2 h和3 h末
测定同等电压强度高频电刺激左侧星状神经节（LSG）时的血压变化，并以血压变化最大值代表LSG功能。在基
础状态和干预 3 h末测定LSG神经活性和血浆去甲肾上腺素(NE)水平。结果 基础状态时，对照组与RSD、
LL-TS、LL-CBS和LL-SCS各干预组高频刺激LSG时诱导的血压变化最大值、LSG神经活性和血浆NE水平比较
差异均无统计学意义(P>0.05)。干预3 h后，RSD、LL-TS、LL-CBS和LL-SCS各干预组LSG功能、神经活性和血
浆NE水平均比对照组明显降低，差异均有统计学意义(P<0.05)。结论 RSD、LL-TS、LL-CBS和LL-SCS这几种
自主神经干预方法都可以显著抑制LSG的功能和活性以及系统交感神经活性。

      【关键词】 自主神经系统；星状神经节；神经活性

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2015）18—2657—05


Effects of different autonomic nervous intervention on the sympathetic nerve system in dogs.
ZHOU Li-ping, YU
Li-lei, WANG Zhuo, HUANG Bing, WANG Song-yun, LIAO Kai, SAREN Gao-wa, JIANG Hong. Department of
Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, CHINA

【Abstract】 Objective To investigate the effects of different autonomic nervous intervention on the sympa-
thetic nerve system in dogs. Methods Forty dogs were randomly divided into the renal sympathetic nerve denerva-
tion (RSD) group (n=8), the low-level tragus stimulation (LL-TS) group (n=8), the low-level carotid baroreceptor stim-
ulation (LL-CBS) group (n=8), the low-level spinal cord stimulation (LL-SCS) group (n=8) and the control group (n=
8). Blood pressure (BP) at baseline and 1 h, 2 h, 3 h after stimulation were recorded, and the maximum BP increasing
value when high frequency stimulation (HFS) was delivered to left stellate ganglion were measured as the function of
the left stellate ganglion. The nerve activity of LSG and the NE level of plasma were also measured. Results At baseline
state, there were no significant differences between the control group and RSD group, LL-TS groups, LL-CBS group,
LL-SCS group in the maximum BP increasing value, the LSG activity and the NE level (P>0.05). After 3 hours of auto-
nomic intervention, the maximum BP increasing value, the LSG activity and the NE level of RSD group, LL-TS group,
LL-CBS group, LL-SCS group were significantly lower than those of the control group. Conclusion Autonomic inter-
vention by RSD, LL-TS, LL-CBS and LL-SCS could significantly decrease the activity and function of left stellate
ganglion and the activity of systematic sympathetic nerve.