标题：岭南地区溃疡性结肠炎的中医证候与内镜分型及黏膜组织分期的相关性研究

      作者：黄新贻 1，李琛琛 2，杨永和 3，吴仕文 4
    (1.海南省中医院内科，海南 海口 570203；
2.广州中医药大学第一附属医院，广东 广州 510405；
3.海南省中医院内科，海南 海口 570203；
4.海南省中医院内科，海南 海口 570203)

      卷次： 2015年26卷17期

      【摘要】 目的 研究岭南地区溃疡性结肠炎的中医证候分别与结肠镜像分型、黏膜组织学分期的相关性，
为中医辨证提供客观依据。方法 收集岭南地区溃疡性结肠炎患者124例，统计不同证候所占比例，分析中医证
型与结肠镜像分型、黏膜组织学分期各自的相关性。结果 岭南地区溃疡性结肠炎临床以大肠湿热、脾虚湿热、
脾胃气虚三类证型多见。结肠镜像分型Ⅰ型以大肠湿热证多见，脾虚湿热证、脾胃气虚证少见(P<0.05)；Ⅱ型三
证出现的概率相当；Ⅲ型以脾胃气虚证、脾虚湿热证多见，大肠湿热证少见(P<0.05)。黏膜组织学分期活动期多
见于大肠湿热证，与脾虚湿热证、脾胃气虚证比较，差异均有统计学意义(P<0.05)；缓解期多见于脾虚湿热证、脾
胃气虚证，与大肠湿热证比较，差异均有统计学意义(P<0.05)。结论 岭南地区溃疡性结肠炎的中医证候与结肠
镜像分型、黏膜组织学分期有明显的相关性，结肠镜及病理组织学检查可作为中医辨证的客观化指标。

      【关键词】 岭南地区；溃疡性结肠炎；中医证候；结肠镜；黏膜组织学

      【中图分类号】 R574.62 【文献标识码】 A 【文章编号】 1003—6350（2015）17—2519—03


Relationship between TCM syndrome of ulcerative colitis in Lingnan area and endoscopic classification and
mucosal tissue staging.
HUANG Xin-yi 1, LI Chen-chen 2, YANG Yong-he 3, WU Shi-wen 4. 1. Department of Internal
Medicine, Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou 570203, Hainan, CHINA; 2. The First Affiliated
Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, CHINA; 3. Department of Internal
Medicine, Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou 570203, Hainan, CHINA; 4. Department of
Internal Medicine, Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou 570203, Hainan, CHINA

【Abstract】 Objective To study the relationship between traditional Chinese medicine (TCM) syndrome of
ulcerative colitis in Lingnan area and endoscopic classification and mucosal tissue staging, providing the objective basis for the
TCM differentiation. Methods A total of 124 patients with ulcerative colitis in Lingnan area were selected. The pro-
portions of different clinical TCM syndrome type were analyzed, and the correlations between TCM syndrome type
and endoscopic classification and mucosal tissue staging were analyzed. Results The common types of TCM syn-
drome of ulcerative colitis in Lingnan area were large intestine damp-heat, spleen-deficiency and dampness-heat, defi-
ciency of spleen and stomach qi. TypeⅠ endoscopic classification was showed more in large intestine damp-heat than
in spleen-deficiency and dampness-heat, deficiency of spleen and stomach qi (P<0.05). There was similar probability
of TypeⅡ endoscopic classification in the three TCM syndrome types. TypeⅢ endoscopic classification was signifi-
cantly less showed in large intestine damp-heat than in spleen-deficiency and dampness-heat, deficiency of spleen and
stomach qi (P<0.05). Large intestine damp-heat was the most common in the active phase of mucosal tissue staging
(P<0.05), while spleen-deficiency and dampness-heat as well as deficiency of spleen and stomach qi occupied main
positions in the relieving phase of mucosal tissue staging (P<0.05). Conclusion The TCM syndrome of ulcerative
colitis in Lingnan area has an significant relationship between endoscopic classification and mucosal tissue staging,
and endoscopic classification and mucosal tissue staging may provide objective basis for the TCM differentiation.