标题：液基薄层细胞学检测在宫颈病变临床筛查中的应用

      作者：粟 燕 1，何 春 2
    (广西壮族自治区妇幼保健院儿科 1、妇产科 2，广西 南宁 530000；

      卷次： 2015年26卷12期

      【摘要】 目的 评估液基薄层细胞学(TCT)检测在宫颈病变临床筛查中的价值。方法 选择2011年8月至
2014年8月在我院就诊经TCT检测异常的宫颈病变患者700例，根据TCT检测结果分为不典型鳞状细胞和腺细
胞(ASCUS)、低度及高度鳞状上皮内病变(LSIL/HSIL)、鳞癌或腺癌(SCC/AC)，并随后进行了高危型人乳头瘤病
毒(HR-HPV)检测和经宫颈活检。将三种方法的检测结果进行对比。结果 700例患者的 TCT检测结果为
ASCUS 364例(52.0%)，LSIL 256例(36.6%)，HSIL 72例(10.3%)，SCC例 8例(1.1%)；宫颈活检结果为正常或炎症
332例(47.4%)，宫颈上皮内瘤变Ⅰ级(CIN I) 216例(30.9%)，宫颈上皮内瘤变Ⅱ级(CINⅡ) 72例(10.3%)，宫颈上皮
内瘤变Ⅲ级(CIN Ⅲ)72例(10.3%)，宫颈癌(CC) 8例(1.1%)；HR-HPV阳性 496例(70.9%)，阴性 204例(29.1%)；
HR-HPV阳性率随着TCT检查分级ASCUS、LSIL、HISL的增高而增高（P<0.05）。结论 TCT与人乳头瘤病毒检
测、宫颈活检符合率均较高，为宫颈病变重要的临床筛查和诊断方法，能及时发现大量的宫颈病变。

      【关键词】 液基薄层细胞学；宫颈活检；宫颈病变；假阴性

      【中图分类号】 R711.74 【文献标识码】 A 【文章编号】 1003—6350（2015）12—1839—03


Application of thinprep cytologic test in the screening of cervical lesions.
SU Yan 1, HE Chun 2. Department of
Paediatrics 1, Department of Gynaecology and Obstetrics 2, Maternal and Child Health Hospital of Guangxi Zhuang
Autonomous Region, Nanning 530000, Guangxi, CHINA

【Abstract】 Objective To evaluate the value of thinprep cytologic test (TCT) in the screening of cervical le-
sions. Methods Seven hundred patients with cervical lesions showing abnormalities in TCT in our hospital from Oc-
tober 2009 to September 2012 were selected. The patients were divided into three classifications according to TCT re-
sults: undetermined significance atypical squamous cells and glandular cells (ASCUS), low-grade squamous intraepi-
thelial lesions (LSIL) or high-grade squamous intraepithelial lesions (HSIL), squamous cell carcinoma (SCC) or ade-
nocarcinoma (AC). The three groups of patients then underwent high-risk human papillomavirus (HR-HPV) testing
and transvaginal cervical biopsy. The test results of the three methods were compared. Results TCT results showed
364 cases (52.0%) of ASCUS, 256 cases (36.6%) of LSIL, 72 cases (10.3%) of HSIL, and 8 cases (1.1%) of SCC cas-
es. Cervical biopsy results showed 332 cases (47.4%) of normal or inflammation, 216 cases (30.9%) of cervical in-
traepithelial neoplasia (CIN)Ⅰ, 72 cases (10.3%) of CINⅡ, 72 cases (10.3%) of CINⅢ, and 8 cases (1.1%) of cervi-
cal cancer. According to HR-HPV testing, 496 cases (70.9% ) were diagnosed as HR-HPV-positive, and 204 cases
(29.1%) were diagnosed as negative. The higher the classification of TCT (ASCUS, LSIL and HISL) was, the higher
the HR-HPV positive rate was (P<0.05). Conclusion TCT is of a high consistent rate with human papillomavirus
testing and cervical biopsy, which could serve as an important clinical diagnostic method for cervical lesions.