标题：双相Ⅰ型障碍缓解期与抑郁发作期患者的神经认知功能比较

      作者：简炜颖，刘文滔
    (广州市惠爱医院情感障碍科，广东 广州 510370)

      卷次： 2015年26卷12期

      【摘要】 目的 比较双相Ⅰ型障碍缓解期患者与抑郁发作期患者的神经认知功能。方法 回顾性分析我
院收治的65例双相Ⅰ型障碍患者的临床资料，其中缓解期患者31例(缓解期组)，抑郁发作期患者34例(发作期
组)，并选取同期健康体检者30例为对照组。对三组受试者的汉密顿量表(HAMD)、大体功能评定量表(GAF)、总
体认知功能评分进行评价和比较。结果 发作期组患者的HAMD评分为(16.53±4.48)分，明显高于缓解期组患
者的(4.21±1.92)分和对照组的(1.75±0.33)分，而缓解期组的HAMD评分明显高于对照组，差异均有统计学意义
(P<0.05)；发作期组的GAF评分为(58.41±15.73)分，明显低于缓解期组的(74.27±14.62)分和对照组的(91.54±4.64)
分，缓解期组的GAF评分明显低于对照组，差异均有统计学意义(P<0.05)；发作期组的总体认知功能评分明显低
于缓解期组和对照组，缓解期组总体认知功能评分明显低于对照组，差异均有统计学意义(P<0.05)。结论 双相
Ⅰ型障碍患者神经认知功能显著降低，其中抑郁发作期神经认知功能低于缓解期。

      【关键词】 双相Ⅰ型障碍；缓解期；抑郁；神经认知功能

      【中图分类号】 R749.4+1 【文献标识码】 A 【文章编号】 1003—6350（2015）12—1751—03


Comparison on neurocognitive function of bipolar Ⅰ disorder patients of euthymia or depression stage.
JIAN
Wei-ying, LIU Wen-tao. Department of Psychiatry, Guangzhou Huiai Hospital, Guangzhou 510370, Guangdong, CHINA

【Abstract】 Objective To compare the neurocognitive function of bipolarⅠ disorder patients of euthymia or
depression stage. Methods Sixty-five patients with bipolarⅠ disorder in our hospital were retrospectively analyzed,
including 31 patients of euthymia stage (euthymia group) and 34 patients of depression stage (depression group). And
30 healthy people were selected as the control group. The Hamilton Depression Scale (HAMD), Global Assessment of
Functioning (GAF) Scale, and general cognitive function level of three groups were tested and compared. Results The
HAMD score of depression group was (16.5±4.48), which was significantly higher than euthymia group (4.21±1.92)
and control group (1.75 ± 0.33), P<0.05. The HAMD score of euthymia group was significantly higher than control
group (P<0.05). The GAF score of depression group was (58.41±15.73), which was significantly lower than euthymia
group (74.27±14.62) and control group (91.54±4.64), P<0.05. The GAF score of euthymia group was significantly
lower than control group (P<0.05). The general cognitive function level of depression group was significantly lower
than euthymia group and control group (P<0.05), and the level of euthymia group was significantly lower than control
group (P<0.05). Conclusion Neurocognitive function of bipolar Ⅰ disorder patients is lower than that of healthy
people, and the function of patients of depression stage is lower than those of euthymia stage.