标题:七氟醚在不同麻醉深度下对老年腹腔镜手术患者术后认知功能的影响
作者:蔡云亮,李安学,李文兵,朱 红,黄 静
(深圳市龙岗区人民医院麻醉科,广东 深圳 518172)
卷次:
2015年26卷11期
【摘要】 目的 分析七氟醚在不同麻醉深度下对老年腹腔镜手术患者术后认知功能的影响。方法 选择
于2013年10月至2014年10月间在本院接受腹腔镜手术治疗的老年患者120例作为研究对象,按照随机数表法
分为两组各60例,观察组接受高浓度七氟醚麻醉(3%~5%,维持患者BIS值35~45),对照组接受低浓度七氟醚麻
醉(1%~2%,维持患者BIS值50~60)。比较两组患者的认知功能、血清炎症因子及神经组织蛋白质S100水平等差
异。结果 (1)认知功能:观察组患者接受高浓度七氟醚麻醉后1 d、7 d的认知功能评分均明显高于对照组,差异
均有统计学意义(P<0.05);(2)炎症因子:观察组患者接受高浓度七氟醚麻醉后7 d的血清白介素-10 (IL-10)、肿瘤
坏死因子-α (TNF-α)、C反应蛋白(CRP)水平均明显低于对照组,差异均有统计学意义(P<0.05);(3)神经组织蛋白
质S100:观察组患者接受高浓度七氟醚麻醉后1 d、7 d的血清S100β蛋白水平明显低于对照组,差异均有统计学
意义(P<0.05)。结论 七氟醚深麻醉有助于减少对老年腹腔镜手术患者术后认知功能的损伤,降低全身炎症因
子及S100β蛋白水平。
【关键词】 腹腔镜手术;七氟醚;认知功能;神经组织蛋白质S100
【中图分类号】 R656 【文献标识码】 A 【文章编号】 1003—6350(2015)11—1604—03
Influence of sevoflurane of different concentrations for anesthesia on elderly patients' cognitive function after
laparoscopic surgery.
CAI Yun-liang, LI An-xue, LI Wen-bing, ZHU Hong, HUANG Jing. Department of
Anesthesiology, People's Hospital of Longgang District of Shenzhen, Shenzhen 518172, Guangdong, CHINA
【Abstract】 Objective To analyze the influence of sevoflurane of different concentrations on elderly patients'
cognitive function after laparoscopic surgery. Methods One hundred and twenty elderly patients received laparoscop-
ic surgery from October 2013 to October 2014 in our hospital were selected as research objects, which were divided in-
to two groups according to random number table, with 60 patients in each group. The observation group applied high con-
centration of sevoflurane for anesthesia (3%~5%, BIS value of 35~45), while the control group used low concentration of
sevoflurane for anesthesia (1%~2%, BIS value of 50~60). The patients' cognitive function, serum levels of inflammatory
factor and S100β protein were compared between the two groups. Results (1) Scores of patients' cognitive function 1 d,
7 d after laparoscopic surgery were significantly higher in the observation group than the control group (P<0.05). (2) Lev-
els of inflammation factors (serum IL-10, TNF-α, CRP) after laparoscopic surgery were significantly lower in the observa-
tion group than control group (P<0.05). (3) The serum S100β levels 1 d, 7 d after laparoscopic surgery were significantly
lower in the observation group than the control group (P<0.05). Conclusion Anesthesia with high concentration of
sevoflurane could reduce damage of cognitive function in elderly patients after laparoscopic surgery, and lower levels
of systemic inflammatory factor and S100β protein.
【Key words】 Laparoscopic surgery; Sevoflurane; Cognitive function; S100β protein
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