标题：BML-111对野百合碱致大鼠肺组织白介素-1β和组织因子的影响

      作者：陈永梅 1，张昭勇 1，陈 玲 1，龚兴瑞 2，向 勇 2
    (湖北医药学院附属太和医院检验科 1、麻醉科 2，湖北 十堰 442000)

      卷次： 2015年26卷11期

      【摘要】 目的 观察脂氧素受体激动剂 BML-111处理对野百合碱 (MCT)导致大鼠肺动脉压力的改
变情况。方法 SD大鼠 36只，按照随机的原则分为 C组、P组和 B组，每组各 12只，P组和 B组皮下注
射野百合碱 50 ?g/g，C组皮下注射相等容量的生理盐水，B组腹腔注射1 mg·kg-1·d-1 BML-111持续28 d。测量
三组SD大鼠的平均肺动脉压力(MPAP)、右心室收缩压(RVSP)及右心室(RV)/[左室(LV)+室间隔(S)]比值，记录肺
组织白介素1β (IL-1β)和组织因子(TF)的水平。结果 P组和B组大鼠的MPAP、RVSP、RV/(LV+S)、肺组织 IL-1β
及 TF水平均高于C组，差异均有统计学意义(P<0.05)；B组大鼠的MPAP、RVSP、RV/(LV+S)、肺组织 IL-1β及 TF
水平均低于P组，差异均有统计学意义(P<0.05)。结论 脂氧素受体激动剂BML-111可有效抑制野百合碱导致
的大鼠肺动脉压力升高，其原理可能与减轻肺组织 IL-1β及 TF水平有关。

      【关键词】 BML-111；野百合碱；白介素-1β；组织因子

      【中图分类号】 R-332 【文献标识码】 A 【文章编号】 1003—6350（2015）11—1566—03


Effect of BML-111 on IL-1β and TF in pulmonary tissue of rats induced by monocrotaline.
CHEN Yong-mei 1,
ZHANG Zhao-yong 1, CHEN Ling 1, GONG Xing-rui 2, XIANG Yong 2. Department of Clinical Laboratory 1, Department of
Anesthesiology 2, Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan 442000, Hubei, CHINA

【Abstract】 Objective To analyzes the effect of BML-111 in treatment of pulmonary arterial hypertension
induced by monocrotaline (MCT). Methods Thirty-six SD rats were randomly divided into three groups (C group, P
group and B group), with 12 rats in each group. Both P group and B group were processed subcutaneous injection of
50 μg/g monocrotaline, while C group received same volume of saline. B group was additionally treated with intraperi-
toneal injection of 1 mg·kg-1·d-1 BML-111 from the day of monocrotaline injection. Mean pulmonary arterial pres-
sure (mPAP), right ventricular systolic pressure (RVSP), ratio of right ventricle to the sum of left ventricle and inter-
ventricular septum [RV/(LV+S)], the pulmonary interleukin-1β (IL-1β) and tissue factor (TF) were observed and as-
sayed. Results The levels of MPAP, RVSP, RV/(LV+S), pulmonary IL-1β and TF in P and B groups were signifi-
cantly higher than those in C group (P<0.05), and the levels in B group were significantly lower than those in P group
(P<0.05). Conclusion BML-111 can improve pulmonary arterial hypertension, which may be attributed to the inhibi-
tory the inflammation of pulmonary tissue.

      【Key words】 BML-111; Monocrotaline; Interleukin-1β (IL-1β); Tissue factor
基金项目：十堰市科技局指导项目（编号：ZD20111016）