标题：调节性T细胞与人乳头瘤病毒感染宫颈癌的相关性研究进展

      作者：辛丹丹 1，佐满珍 1，刘朝奇 2
    （1.三峡大学人民医院妇产科，湖北 宜昌 443000；
2.三峡大学分子生物学研究所，湖北 宜昌 443002）

      卷次： 2015年26卷10期

      【摘要】 人乳头瘤病毒(HPV)的持续感染已被证实是宫颈癌发生的必要因素。HPV病毒在感染机体的过程
中，不仅可以诱导机体产生特异性的免疫应答，同时也可以逃避机体的免疫应答，从而使机体产生免疫耐受，最
终导致宫颈癌的发生。有研究显示调节性T细胞(Treg)参与了病毒引起的免疫应答，它可以维持机体对病毒的
免疫耐受，最终引起病毒持续感染。既往关于Treg细胞与宫颈癌发生的关系主要集中在外周血中Treg细胞相关
的细胞因子，很少关注Treg细胞与HPV的关系，本文将对Treg 细胞与HPV存在状态的关系以及在HPV感染引
起宫颈癌过程中的作用进行综述。

      【关键词】 人乳头瘤病毒；宫颈癌；调节性T细胞；免疫耐受

      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2015）10—1480—04


Correlation between regulatory T cell and HPV infectedcervical cancer.
XIN Dan-dan 1, ZUO Man-zhen 1, LIU
Chao-qi 2. 1. Department of Obstetrics and Gynecology, People's Hospital of China Three Gorges University, Yichang
443000, Hubei, CHINA; 2. Institute of Molecular and Biology, Three Gorges University, Yichang 443002, Hubei, CHINA
【Abstract】 Persistent infection of human papilloma virus (HPV) has been proved to be a necessary cause of
cervical cancer. During the infection process, HPV can not only induce specific immune response but also evade im-
mune clean, which result in immune tolerance and eventually lead to the occurrence of cervical cancer. Increasing re-
searches have shown that regulatory T cells (Treg) was involved in the immune response caused by virus. The Treg
cells helped maintain the body's immune tolerance, which can eventually lead to persistent infection of the virus. Previ-
ous researches about the correlation between Treg cells and cervical cancer focused mostly on the cytokines in periph-
eral blood, while little attention was paid to the correlation between Treg cell and HPV. Therefore, interaction between
Treg cell and HPV in different infection stages and the role of Treg cell in cervical cancer are reviewed in this paper.

      【Key words】 Human papilloma virus; Cervical cancer; Regulatory T cells; Immune tolerance
基金项目：三峡大学2014年硕士学位论文培优基金资助（编号：2014PY051）