标题：长链非编码RNAMEG3在肿瘤中的作用及机制

      作者：苏冬梅 1，邹龄松 2，何融泉 3，陈 罡 2
    (1.玉林市红十字会医院病理科，广西 玉林 537000；
2.广西医科大学第一附属医院病理科，广西 南宁 530021；
3.广西医科大学第一附属医院肿瘤内科，广西 南宁 530021)

      卷次： 2015年26卷10期

      【摘要】 MEG3是一种印记基因，位于人类染色体14q32.3的DLK1-MEG3位点，属于长链非编码RNA，在肿瘤
组织中表达异常，可通过不同的机制参与肿瘤的发生发展。本文就MEG3在肿瘤中的作用及其机制做一综述。

      【关键词】 MEG3；肿瘤；作用；机制；长链非编码RNA

      【中图分类号】 R73-3 【文献标识码】 A 【文章编号】 1003—6350（2015）10—1472—03


Functions and mechanisms of lncRNA MEG3 in tumors.
SU Dong-mei 1, ZOU Ling-song 2, HE Rong-quan 3, CHEN
Gang 2. 1. Department of Pathology, Red Cross Hospital of Yulin City, Yulin 537000, Guangxi, CHINA; 2. Department of
Pathology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, CHINA; 3. Department
of Medical Oncology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, CHINA
【Abstract】 Maternally expressed gene 3 (MEG3) is an imprinted gene located at the imprinted DLK1-MEG3
locus in chromosome 14q32.3. MEG3 is a long noncoding RNA (lncRNA) and it expresses aberrantly in tumor tis-
sues. MEG3 plays a vital role in the genesis and development of tumor via multiple mechanisms. In this review, we fo-
cus on the mechanisms of MEG3 in tumor.

      【Key words】 MEG3; Tumor; Mechanism; Long noncoding RNA (lncRNA)