标题：三联疗法与序贯疗法根除长期服用非甾体类抗炎药人群幽门螺旋杆菌的疗效观察

      作者：文 毅，陈宇宁，钟俊锋
    (惠州市第三人民医院消化内科，广东 惠州 516002)

      卷次： 2015年26卷9期

      【摘要】 目的 观察长期服用非甾体类抗炎药(NSAID)人群采用三联疗法与序贯疗法根除幽门螺旋杆菌
(Hp)的疗效。方法 选取于 2012年 6月至 2014年 6月期间来我院接受治疗的 84例感染Hp的患者作为研究对
象。据随机数表法将患者分成观察组和对照组各42例，对照组患者采用三联疗法治疗，观察组患者则采用序贯
疗法，观察两种不同治疗方式根除Hp感染的效果。结果 对照组患者治疗后Hp转阴率为 76.20%，观察组为
80.95%，两组比较差异无统计学意义(P>0.05)。两组患者治疗后，对照组不良反应发生率为 11.90%，观察组为
9.52%，两组比较差异无统计学意义(P>0.05)。对照组患者治疗后总有效率为71.43%，观察组为92.86%，两组比
较差异有统计学意义(P<0.05)。结论 序贯疗法能有效抑制幽门螺旋杆菌对非甾体药物产生耐药性，增强药物
药效，同时降低非甾体药物对患者胃部黏膜损害，提高药物有效治愈率，值得广泛使用。

      【关键词】 非甾体类抗炎药；三联疗法；序贯疗法；幽门螺旋杆菌

      【中图分类号】 R378.2 【文献标识码】 A 【文章编号】 1003—6350（2015）09—1339—03


Clinical efficacy of triple therapy versus sequential therapy for eradicating Helicobacter pylori in patients with
long-term use of non-steroidal anti-inflammatory drug.
WEN Yi, CHEN Yu-ning, ZHONG Jun-feng. Department
of Gastroenterology, the Third People's Hospital of Huizhou City, Huizhou 516002, Guangdong, CHINA

【Abstract】 Objective To compare the efficacy of triple therapy and sequential therapy for eradicating Helico-
bacter pylori (HP) in patients with long-term use of non-steroidal anti-inflammatory drug (NSAID). Methods Eighty-four
patients infected with HP from June 2012 to June 2014 in our hospital were enrolled in the study. The patients were ran-
domly divided into study and control group based on random number table. The control group (n=42) was treated
with triple therapy, while the study group was treated with sequential therapy. The effects of the two different treat-
ments for eradicating Hp were observed. Results After treatment, the Hp negative rate was 76.20% in the control
group and 80.95% in the study group, with no statistically significant difference between the two groups (χ2=0.282 8,
P=0.594 0). After treatment, the incidence of adverse reactions was 11.90% in the control group and 9.52% in the
study group, with no statistically significant difference between the two groups (P>0.05). The total effective rate was
71.43% in the control group and 92.86% in the study group, with a significant difference (χ 2=2.188 2, P=0.028 7).
Conclusion Sequential therapy can effectively inhibit the resistance of Hp to non-steroidal anti-inflammatory drug,
improve the drug's efficacy, reduce the gastric mucosal injury, and improve the cure rate, which is worth to be widely
applied.