标题：结直肠癌与肠道菌群关系的研究进展

      作者：魏莉平 综述，刘诚明 审校
    (新疆医科大学附属肿瘤医院检验科，新疆 乌鲁木齐 830011)

      卷次： 2015年26卷9期

      【摘要】 人体肠道微生态系统在健康状态下具有维持肠道正常结构，促进肠道对营养物质的消化吸收，抵
抗病原微生物的侵入及调节肠道免疫应答等重要功能。有研究表明肠道菌群结构或数目的改变与结直肠癌的
发生发展密切相关。了解肠道菌群参与结直肠癌发生的机制，有助于指导临床对结直肠癌患者的治疗及做好预
防工作。目前肠道菌群在结肠癌中的具体发病机制仍不明确，本文将肠道菌群在结直肠癌发生发展中的菌群结
构变化和致病机制最新研究进展进行综述。

      【关键词】 肠道菌群；结直肠癌；发病机制

      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2015）09—1328—03


Progress on the relationship between colorectal cancer and intestinal flora.
WEI Li-ping, LIU Cheng-ming.
Department of Clinical Laboratory, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011,
Xinjiang, CHINA
【Abstract】 The human gut micro ecology system in health state plays the roles of maintaining the normal
structure, promoting the intestinal digestion and absorption of nutrients, resisting the invasion of pathogenic microor-
ganism, regulating the intestinal immune response. Studies have shown that the change of structure or number of intes-
tinal flora is closely related to the occurrence of colorectal cancer development. To understand the mechanism of intes-
tinal flora in colorectal cancer can help to guide the clinical treatment of colorectal cancer patients and to do a good
job of prevention. But the intestinal flora in the colon specific pathogenesis is still unclear. This article will review lat-
est research progress of gut flora in its flora structure change in the development of colorectal cancer and pathogenic
mechanisms.

      【Key words】 Intestinal flora; Colorectal cancer; Pathogenesis