标题：血液灌流联合血液透析对百草枯中毒患者血清MDA和SOD的影响

      作者：雷 莉，胡大军
    (宜昌市第二人民医院肾内科，湖北 宜昌 443000)

      卷次： 2015年26卷9期

      【摘要】 目的 探讨血液灌流联合血液透析对百草枯中毒患者血清丙二醛(Malondial Dehyde, MDA)和
超氧化物歧化酶(Super Oxide Dismutase, SOD)的影响。方法 2012年 1月至 2013年 12月，选择我院肾内科收
治的服用百草枯患者 98例，随机分为A、B两组，每组 49例。A组给予单纯血液灌流治疗，B组给予血液灌流
联合血液透析，应用MDA测试盒和T-SOD测试盒，分别检测两组患者两次治疗前、后血清中MDA和 SOD的
浓度。结果 A组患者死亡率为46.94%，B组死亡率为42.86%，差异无统计学意义(P>0.05)；A、B组患者两次治
疗后体内SOD浓度较治疗前均提高(P<0.05)，第二次治疗前体内SOD浓度较第一次治疗后下降(P<0.05)；A、B组
患者两次治疗后体内MDA浓度较治疗前均下降(P<0.05)；第二次治疗前体内MDA浓度较第一次治疗后上升
(P<0.05)；两次血液净化治疗后，A组和B组患者间血清SOD活力升高值和MDA下降值比较，差异均无统计学意
义(P>0.05)。结论 两种血液净化治疗方法均能使百草枯中毒患者体内SOD活力升高，MDA含量下降，血液灌
流治疗起主导作用。

      【关键词】 血液灌流；血液透析；百草枯；超氧化物歧化酶；丙二醛

      【中图分类号】 R595.4 【文献标识码】 A 【文章编号】 1003—6350（2015）09—1313—03


Effects of hemoperfusion combined with hemodialysis on the superoxide dismutase and malondial dehyde in
serum of patients with paraquat poisoning.
LEI Li, HU Da-jun. Department of Nephrology, the Second People's
Hospital of Yichang, Yichang 443000, Hubei, CHINA

【Abstract】 Objective To explore the effects on superoxide dismutase (SOD) and malondial dehyde
(MDA) in serum of patients with paraquat poisoning when treated by hemoperfusion combined with hemodialysis.
Methods Ninety-eight patients with paraquat poisoning in Department of Nephrology in our hospital from January
2012 to December 2012 were selected, which were divided into group A and B randomly, with 49 patients in each
group. The patients in group A were given simple hemoperfusion treatment, while the patients in group B were given
hemoperfusion combined hemodialysis. MDA checkerboard and T-SOD checkerboard were applied to detect the lev-
els of MDA and SOD in serum before and after treatment in the two groups. Results The mortality of patients was
46.94% in group A and 42.86% in group B, with no statistically significant difference (P>0.05). The SOD levels of pa-
tients in group A and B after two treatments (the first treatment and the second treatment) were both higher than before
treatments (P<0.05), and the levels before the second treatment were lower than those after the first treatment (P<
0.05). The MDA levels of patients in group A and B after two treatments were both lower than before treatments (P<