标题：阻塞性黄疸患者总胆汁酸与血脂水平分析

      作者：吕 红 1，胡汉宁 2，程小欢 2
    (1.中国建筑第三工程局武汉中心医院检验科，湖北 武汉 430070；
2.武汉大学中南医院检验科，湖北 武汉 430000)

      卷次： 2015年26卷8期

      【摘要】 目的 探讨阻塞性黄疸患者总胆汁酸(TBA)与血脂水平变化情况，分析TBA与血脂水平的相关
性。方法 选择2012年8月至2013年12月我院收治的104例阻塞性黄疸患者作为病例组，根据TBA不同水平
分为低水平组和高水平组，选择同时期门诊健康体检者 80例作为对照组，比较各组对象的TBA及血脂水平。
结果 病例组总胆固醇(TC)、三酰甘油(TG)、TBA、总胆红素(T-Bil)、直接胆红素(D-Bil)均高于对照组，高密度脂
蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A1(apo A1)、脂蛋白(α)[Lp(α)]均低于对照组，差异均有统计学意
义(P<0.05)；高水平组TC、TG、T-Bil、D-Bil均高于低水平组，HDL-C、apo A1、LDL-C、Lp(α)均低于低水平组，差异
均有统计学意义(P<0.05)；相关性分析结果显示，TBA与 TC、TG、T-Bil、D-Bil呈显著正相关(r>0，P<0.05)，与
LDL-C、HDL-C、apo A1、Lp(α)呈显著负相关(r<0，P<0.05)。结论 阻塞性黄疸患者伴有程度不同的脂代谢紊乱，
总胆汁酸可能起着重要促进作用。

      【关键词】 阻塞性黄疸；总胆汁酸；血脂；相关性

      【中图分类号】 R575.6 【文献标识码】 A 【文章编号】 1003—6350（2015）08—1162—03


Analysis of total bile acid and blood lipid levels in patients with obstructive jaundice.
LV Hong 1, HU Han-ning 2,
CHENG Xiao-Huan 2. 1. Department of Clinical Laboratory, Wuhan Central Hospital, Chinese Construction Third
Engineering Bureau, Wuhan 430070, Hubei, CHINA; 2. Department of Clinical Laboratory, Zhongnan Hospital of Wuhan
University, Wuhan 430000, Hubei, CHINA

【Abstract】 Objective To investigate the changes of total bile acid (TBA) and blood lipid level in patients
with obstructive jaundice, and to analyze the correlation between TBA and blood lipid level. Methods One hundred
and four patients with obstructive jaundice from August 2012 to December 2013 in our hospital were selected as case
group, which were then divided into low level group and high level group according to the level of total bile acids.
Eighty healthy individuals in the same period in the Outpatient Department were selected as control group. The level
of blood lipid and TBA were compared between the three groups. Results Total cholesterol (TC), triglyceride (TG),
TBA, total bilirubin (T-Bil) and direct bilirubin (D-Bil) in the case group were all significantly higher than those in the
control group (P<0.05), while high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol
(LDL-C), Apolipoprotein A1 (apoA1), Lipoprotein (α) [Lp(α)] were all significantly lower than those in the control
group (P<0.05). TC, TG, T-Bil, D-Bil in high level group were significantly higher than those in the low level group
(P<0.05), while HDL-C, apoA1, LDL-C, Lp(α) were significantly lower (P<0.05). Correlation analysis results showed
that TAB was positively associated with TC, TG, T-Bil, D-Bil (r>0, P<0.05), and negatively correlated with HDL-C,
apoA1, LDL-C, Lp(α) (r<0, P<0.05). Conclusion Patients with obstructive jaundice have different degrees of disor-
der in lipid metabolism, and total bile acids may play an important role in promoting the disorder.

      【Key words】 Obstructive jaundice; Total bile acid; Blood lipid; Correlation
基金项目：湖北省自然科学基金(编号：2012FFB04411)、武汉大学院内基金(编号：201105)