标题：胰岛素泵短期强化治疗对糖尿病合并足溃疡患者氧化应激状态的影响

      作者：解为慈，张大林
    (天门市第一人民医院血液内分泌科，湖北 天门 431700)

      卷次： 2015年26卷7期

      【摘要】 目的 探讨胰岛素泵短期强化治疗对糖尿病合并足溃疡患者氧化应激状态的影响。方法 将88
例糖尿病合并足溃疡患者随机分为观察组和对照组各44例，对照组接受常规皮下注射胰岛素治疗，观察组接受
短期胰岛素泵强化治疗方案，记录两组患者治疗前后的血浆丙二醛含量(MDA)、超氧化物歧化酶水平(SOD)、空
腹血糖水平(FPG)、糖化血红蛋白(HbA1c)、餐后 2 h血糖(2 hPG)和溃疡面积，并记录治疗两周后的溃疡愈合情
况。结果 观察组治疗后1周、2周后的MDA、HbA1c、2 hPG和FPG均低于对照组 (P<0.05)，治疗后1周、2周后的
SOD均高于对照组(P<0.05)；溃疡面积在治疗后 1周、2周亦显著小于对照组(P<0.05)；Pearson线性相关分析显
示：治疗前及治疗后1周、2周的MDA与溃疡面积呈正相关(P<0.05)，而治疗前及治疗后1周、2周的SOD与溃疡
面积呈负相关(P<0.05)。结论 胰岛素泵短期强化治疗可以有效改善糖尿病合并足溃疡患者各项指标，减轻氧
化应激状态，从而促进糖尿病患者溃疡的愈合。

      【关键词】 糖尿病；胰岛素泵；糖尿病足溃疡；氧化应激

      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2015）07—0952—03


Influences of short-term insulin pump intensive treatment on oxidative stress in patients with diabetic foot
ulcer.
XIE Wei-ci, ZHANG Da-lin. Department of Endocrinology, the First People's Hospital of Tianmen, Tianmen
431700, Hubei, CHINA

【Abstract】 Objective To discuss the influences of short-term insulin pump intensive treatment on oxidative
stress in patients with diabetic foot ulcer. Methods Eighty-eight patients with diabetic foot ulcer were randomly di-
vided into observation group (n=44) and control group (n=44). The control group received routine subcutaneous injec-
tions of insulin therapy, and observation group received short-term insulin pump intensive treatment. Plasma malondial-
dehyde (MDA), superoxide dismutase (SOD), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), 2 h post-
prandial blood glucose (2 hPG), ulcer area were recorded before and after treatment. Results MDA, HbA1c, 2 hPG,
FPG of the observation group were significantly lower than those of control group after 1, 2 weeks of treatment
(P<0.05), while SOD was significantly higher than that of control group after 1, 2 weeks of treatment (P<0.05). Ulcer
area of the observation group was significantly less than that of control group after 1, 2 weeks of treatment (P<0.05).
Pearson correlation analysis showed that MDA were positively correlated with ulcer area before and after 1, 2 weeks
of treatment (P<0.05), while SOD were negatively correlated with ulcer area before and after 1, 2 weeks of treatment
(P<0.05). Conclusion Short-term insulin pump intensive therapy can effectively improve the indicators of patients
with diabetic foot ulcers, and decrease oxidative stress so as to promote the healing of ulcer in patients.

      【Key words】 Diabetes; Insulin pump; Diabetic foot ulcer; Oxidative stress
基金项目：湖北省科技厅项目（编号：EK2013D210014000788）